AI Article Synopsis
- Fibroblast-like synoviocytes (FLS) are key cells in the synovial membrane of joints, crucial for maintaining normal joint function by producing important substances.
- In conditions like rheumatoid arthritis (RA), FLS can become overactive and contribute to chronic inflammation and joint damage.
- Targeting FLS may offer therapeutic benefits for autoimmune joint disorders without the side effects associated with traditional immunosuppressive treatments.
Article Abstract
Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components of the inner layer of the joint capsule, referred to as the synovial membrane. They can be found in both layers of this synovial membrane and contribute to normal joint function by producing extracellular matrix components and lubricants. However, under inflammatory conditions like in rheumatoid arthritis (RA), they may start to proliferate, undergo phenotypical changes and become central elements in the perpetuation of inflammation through their direct and indirect destructive functions. Their importance in autoimmune joint disorders makes them attractive cellular targets, and as mesenchymal-derived cells, their inhibition may be carried out without immunosuppressive consequences. Here, we aim to give an overview of our current understanding of the target potential of these cells in RA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279838 | PMC |
| http://dx.doi.org/10.1136/annrheumdis-2021-222021 | DOI Listing |
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