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Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.
Int J Psychiatry Med
January 2025
The Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Objective: Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this population. This manuscript reviews the pathophysiological basis of the connection between BD and cardiovascular diseases, highlighting their shared mechanisms, reciprocal interactions, and relevant prevention and treatment strategies.
Methods: For this narrative review, a search was carried out on PubMed using the keywords bipolar disorder, cardiovascular diseases, and cardiovascular risk factors.
Precision Oncology: A Global Perspective on Implementation and Policy Development.
JCO Glob Oncol
January 2025
International Cancer Patient Coalition, Brussels, Belgium.
Despite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full potential for advancing care and prevention remains unrealized. The benefits are currently accessible to only limited patient segments because of multifaceted barriers. Successful implementation hinges on various factors-scientific complexities not limited to technical, clinical, regulatory, economic, administrative, and health care policy-related challenges.
View Article and Find Full Text PDFMental and Oral Health: A Dual Frontier in Healthcare Integration and Prevention.
Cureus
December 2024
Public Health Dentistry, Sri Ramaswamy Memorial (SRM) Kattankulathur Dental College and Hospital, Sri Ramaswamy Memorial Institute of Science and Technology (SRMIST), Chennai, IND.
Mental and oral health are interrelated, and problems in one area usually affect the other. This review discusses the complex relationships between oral and mental health, particularly the psychosocial challenges faced by individuals with mental health disorders in maintaining oral hygiene, including stigma, lack of access to care, and financial barriers. It also discusses how psychiatric conditions influence oral health, with regard to issues such as dry mouth, gum disease, and tooth decay, and how poor oral health can aggravate mental well-being.
View Article and Find Full Text PDFThe early market access vehicle - An innovative demand-driven model to catalyse introduction of new optimal health products in low- and middle-income countries.
Health Policy Open
June 2025
Strategy Division, Unitaid, Geneva, Switzerland.
Low-and middle-income countries (LMICs) account for a significant proportion of the burden of disease for communicable illnesses globally; with malaria, tuberculosis (TB), and HIV/AIDS being the leading causes of death. Despite this disparity, LMICs often have limited or delayed access to newer optimal health products compared to high-income countries (HICs). This limitation in access, driven by a myriad of barriers, undermines the potential health benefits that could be gained in LMICs through the introduction of better health products.
View Article and Find Full Text PDFArtificial intelligence and blockchain in clinical trials: enhancing data governance efficiency, integrity, and transparency.
Bioanalysis
January 2025
Centre of Mathematics, Universidade do Minho, Braga, Portugal.
This article examines the transformative potential of blockchain technology and its integration with artificial intelligence (AI) in clinical trials, focusing on their combined ability to enhance integrity, operational efficiency, and transparency in the data governance. Through an in-depth analysis of recent advancements, the article highlights how blockchain and AI address critical challenges, including patient data privacy, regulatory compliance, and security. The article also identifies key barriers to adoption in the mentioned integration, such as scalability limitations, association with existing healthcare systems, and high implementation costs.
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