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The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn's Disease.
Adv Ther
December 2024
Kennedy Institute, Translational Gastroenterology Unit and Biomedical Research Centre, University of Oxford, Oxford, UK.
Introduction: Bowel urgency has recently been recognized as a Crohn's disease (CD) symptom that substantially impacts patients' quality of life. The Urgency NRS is a single-item patient-reported outcome measure assessing bowel urgency severity in the past 24 h (0-10 scale). We aimed to evaluate the psychometric properties of the Urgency Numeric Rating Scale (NRS) in adults with moderately to severely active CD and to estimate thresholds for meaningful improvement and bowel urgency remission.
View Article and Find Full Text PDFAn assessment of seven closed system transfer devices in accordance with the 2015 NIOSH vapor containment performance protocol.
J Oncol Pharm Pract
December 2024
Division of Practice Advancement and Clinical Education, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Introduction: The purpose of this study was to assess and compare the effectiveness of seven different closed system transfer device (CSTD) product lines following the 2015 NIOSH Vapor Containment Performance Protocol, using a Gasmet™ DX5000 Terra multigas FTIR analyzer.
Methods: Seven different CSTD systems were assessed using a two-task evaluation on their capacity to contain the NIOSH-specified challenge agent, 70% isopropyl alcohol (IPA). Task 1 simulated reconstitution and compounding steps while Task 2 simulated compounding and administration steps.
Pixel to Pathology: A Prospective Cross-Sectional Study on the Role of Multidetector Computed Tomography in the Evaluation of Malignant Large Bowel Lesions With Histopathological Correlation.
Cureus
October 2024
Radiodiagnosis, Mahatma Gandhi Medical College and Research Institute, Pondicherry, IND.
Background And Objectives: Colorectal lesions can present as a mass or as focal or diffuse thickening of the colon wall and may also be associated with abnormalities in the perienteric region. Multidetector computed tomography (MDCT) enables simultaneous imaging of both extracolonic structures and the gut wall. It is instrumental in assessing tumor extent, detecting pericolic dissemination, including lymph node involvement, and identifying metastases.
View Article and Find Full Text PDFDiel asynchrony in the expanded characteristics of toxic cyanobacterial blooms revealed by integrated metabolomics and metagenomics.
J Hazard Mater
December 2024
Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China. Electronic address:
Article Synopsis
- Researchers developed a metabolomics protocol for Lake Taihu, identifying the minimum biomass required for analyses and the times when metabolomes are stable, with phytoplankton requiring 475-950 µg DW and whole-water samples needing 940-1760 µg DW.
- The study found that phytoplankton (F) and whole-water (W) microbiomes showed asynchronous changes in taxonomical composition and metabolic states throughout the day, with F peaking in metabolic activity between 12-17 pm and W around 12 pm, revealing a significant overlap of 482 metabolites.
- A deeper examination highlighted differences in metabolic processes, such as carbon metabolism in F and amino acid metabolism in W, along with insights into genetic diversity and interactions
An improved energy saving clustering method for IWSN based on Gaussian mutation adaptive artificial fish swarm algorithm.
Sci Rep
November 2024
Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
The current industrial wireless sensor network (IWSN) cluster routing methods suffer from energy inefficiency. Designing efficient cluster-based routing protocols is crucial for improving network performance and energy efficiency. Therefore, this paper first designs a new clustering model to achieve efficient cluster head (CH) selection and data transmission performance by comprehensively considering multiple key factors such as CH energy, base station (BS) distance, packet loss rate, and data delay.
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