The published biomedical articles are the best source of knowledge to understand the importance of biomedical entities such as disease, drugs, and their role in different patient population groups. The number of biomedical literature available and being published is increasing at an exponential rate with the use of large scale experimental techniques. Manual extraction of such information is becoming extremely difficult because of the huge number of biomedical literature available. Alternatively, text mining approaches receive much interest within biomedicine by providing automatic extraction of such information in more structured format from the unstructured biomedical text. Here, a text mining protocol to extract the patient population information, to identify the disease and drug mentions in PubMed titles and abstracts, and a simple information retrieval approach to retrieve a list of relevant documents for a user query are presented. The text mining protocol presented in this chapter is useful for retrieving information on drugs for patients with a specific disease. The protocol covers three major text mining tasks, namely, information retrieval, information extraction, and knowledge discovery.
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http://dx.doi.org/10.1007/978-1-0716-2305-3_1 | DOI Listing |
Expert Opin Drug Saf
January 2025
Department of Endocrinology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Background: Fulminant type 1 diabetes mellitus (FT1DM) is a severe subtype of type 1 diabetes characterized by rapid onset, metabolic disturbances, and irreversible insulin secretion failure. Recent studies have suggested associations between FT1DM and certain medications, warranting further investigation.
Objectives: This study aims to analyze drugs associated with an increased risk of FT1DM using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Sensors (Basel)
December 2024
School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi 214122, China.
With the rapid development of blockchain technology, fraudulent activities have significantly increased, posing a major threat to the personal assets of blockchain users. The blockchain transaction network formed during user transactions can be represented as a graph consisting of nodes and edges, making it suitable for a graph data structure. Fraudulent nodes in the transaction network are referred to as anomalous nodes.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Hybrid Technology Hub, Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0372 Oslo, Norway.
: Tumor organoid and tumor-on-chip (ToC) platforms replicate aspects of the anatomical and physiological states of tumors. They, therefore, serve as models for investigating tumor microenvironments, metastasis, and immune interactions, especially for precision drug testing. To map the changing research diversity and focus in this field, we performed a quality-controlled text analysis of categorized academic publications and clinical studies.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Melatonin is a hormone released by the pineal gland that regulates the sleep-wake cycle. It has been widely studied for its therapeutic effects on Alzheimer's disease (AD), particularly through the amyloidosis, oxidative stress, and neuroinflammation pathways. Nevertheless, the mechanisms through which it exerts its neuroprotective effects in AD are still largely unknown.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Sustainable Mining Engineering Research Group, Department of Mining, Mechanic, Energetic and Construction Engineering, Higher Technical School of Engineering, University of Huelva, 21007 Huelva, Spain.
This article shows the behavior of the corrosive effect of acid mine water on carbon steel metal alloys. Mining equipment, composed of various steel alloys, is particularly prone to damage from highly acidic water. This corrosion results in material thinning, brittle fractures, fatigue cracks, and ultimately, equipment failure.
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