AI Article Synopsis
- Researchers developed a new type of photosensitizer, called AIE assemblies, which can effectively agglutinate bacteria for photodynamic therapy (PDT) without being invasive.
- The design involved an AIE-active molecule called CTRA, engineered to produce singlet oxygen (O) thanks to its donor and acceptor components.
- By coassembling CTRA with an amphiphile (DGal) that has a β-d-galactose headgroup, they created highly effective photosensitizer assemblies, achieving nearly 100% efficacy against targeted bacteria.
Article Abstract
Aggregation-induced emission (AIE) photosensitizer assemblies capable of inducing bacterial agglutination were fabricated to achieve a high PDT efficacy in a noninvasive manner. An AIE-active molecule CTRA was designed to bear the donor and acceptor subunits for singlet oxygen (O) generation. An amphiphile DGal with a β-d-galactose headgroup was introduced to coassemble for the photosensitizer assemblies bearing glycosyls for bacteria capture as well as to tune the O generation of CTRA. At the optimal combination of two components, a highly efficient noninvasive PDT activity with nearly 100% effectiveness against was realized.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsabm.2c00370 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!