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| http://dx.doi.org/10.1016/j.jdcr.2022.05.006 | DOI Listing |
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The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepatoblastoma.
Diagn Pathol
January 2025
Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Background: Hepatoblastoma (HB) is the most common malignant solid tumor of the liver in children and is a fatal disease with a poor prognosis. Therefore, indicators that can be used for the early prediction of the HB prognosis are necessary. Sodium glucose cotransporter 2 (SGLT2) is a glucose transporter protein present in the proximal renal tubules.
View Article and Find Full Text PDFAnalysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients.
Cancer Rep (Hoboken)
November 2024
Neuroscience and Neurogenetics Research Team (ERNN), Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Background: Wilms tumour (WT), the second most reported childhood cancer in Morocco, is a malignant kidney tumour that affects children under 15 years old. Prognosis has improved with the adoption of multimodal treatment. However, data on WT in Morocco remain limited.
View Article and Find Full Text PDFEpidemiological and anatomopathological profile of colorectal cancer in Northern Morocco between 2017 and 2019.
Arab J Gastroenterol
November 2024
Intelligent Automation & BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University-Tetouan, Morocco.
Article Synopsis
- - Colorectal cancer (CRC) is a significant public health issue globally and is the third most common cancer, with limited epidemiological data in northern Morocco; this study aims to fill that gap by examining CRC characteristics in the region.
- - The retrospective study at the Ahmed Ben Zayed Al Nahyan Regional Oncology Center identified 142 CRC patients from 2017 to 2019, revealing a mean age of 58 years, predominantly affected males, and a high incidence of rectal tumors (44%).
- - Most patients were diagnosed at advanced stages (83%), with liver metastasis being the most common, highlighting the need for larger studies to better understand CRC's impact in Morocco and inform future interventions.
Comparison of clinicopathological characteristics, efficacy of neoadjuvant therapy, and prognosis in HER2-low and HER2-ultralow breast cancer.
Diagn Pathol
September 2024
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430000, China.
Background: This study aims to analyze potential differences in clinicopathology, efficacy of neoadjuvant therapy (NAT), and clinical outcome among HER2-null, HER2-ultralow and HER2-low breast cancers.
Methods: Consecutive cases of HER2-negative breast cancer that received NAT were included. They were classified as HER2-null (no staining), HER2-ultralow (incomplete faint staining in ≤ 10% of tumour cells) and HER2-low (HER2-1 + or HER2-2+, in situ hybridisation negative).
Regulatory miR-SNP rs4636297A > G in miR-126 is linked to increased risk of rigidity feature in patients with Parkinson's disease.
Int J Neurosci
September 2024
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Introduction: A growing body of strong evidence shows that the dysfunction of miRNAs plays key roles in the development and progression of Parkinson's disease (PD), however, little data has been reported on the association of their SNPs with PD susceptibility. In this study, we investigated the association of regulatory miR-SNP rs4636297A > G with a functional effect on the expression of miRNA-126, as a key dysregulated miRNA in the PD, with the susceptibility and clinical features of the PD.
Methods And Materials: In current study, we included a population consisting of 120 patients with PD and 120 clinically healthy individuals, and their blood samples were taken.
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