AI Article Synopsis
- Pancreatic adenocarcinoma (PAAD) is a highly malignant digestive tumor, and studies show that high expression of Glucose transporter 1 (GLUT1) correlates with aggressive tumor progression and poor prognosis in various cancers, including PAAD.
- A detailed analysis revealed that GLUT1 expression is significantly elevated in PAAD, and higher levels of GLUT1 are linked to worse patient outcomes, suggesting it could be a potential prognostic marker.
- The study also identified the regulatory role of non-coding RNAs (specifically the CASC19/miR-140-5p axis) in GLUT1 expression and highlighted GLUT1’s involvement in tumor metastasis and its relationship with immune indicators.
Article Abstract
Pancreatic adenocarcinoma (PAAD) is a digestive tumor with extremely high malignancy. Previous studies have reported that Glucose transporter 1 (GLUT1) contributes to the aggressive tumor progression in various cancer types and indicates an unfavorable prognosis. However, the function of GLUT1 in PAAD remains largely unclear. Through pan-cancer analysis of GLUT1 expression, GLUT1 expression was significantly higher in several cancer types including PAAD. Survival analysis based on the GLUT1 expression showed that GLUT1 could serve as a predictor of poor prognosis. We further predicted and screened the candidate non-coding RNAs (ncRNAs) upstream of the GLUT1 mRNA through correlation analysis, and found that the CASC19/miR-140-5p axis contributing to the regulation of GLUT1 expression. Our study suggested a link exists between GLUT1 expression and selected immunity-related indicators. Subsequent analysis revealed overexpression of GLUT1 in pancreatic cancer specimens and patients with highly expressed GLUT1 expression had worse prognosis. Based on the significantly different expression of GLUT1, the possibility that GLUT1 participated in tumor progression was identified. Using online public databases, genes co-expressed with GLUT1 were screened and enriched to metastasis-related pathways by enrichment analysis. Additionally, functional assays verified that GLUT1 could function in the metastatic process of PAAD cancer cells. Therefore, we proposed that GLUT1 might serve as a role in tumor immunity and tumor metastasis, and was expected to be a prognostic factor in PAAD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174867 | PMC |
| http://dx.doi.org/10.7150/jca.72161 | DOI Listing |
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