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Cavitation induced fracture of intact brain tissue. | LitMetric

Cavitation induced fracture of intact brain tissue.

Biophys J

Chemical Engineering Department, University of Massachusetts, Amherst, Massachusetts. Electronic address:

Published: July 2022

AI Article Synopsis

Article Abstract

Nonpenetrating traumatic brain injuries (TBIs) are linked to cavitation. The structural organization of the brain makes it particularly susceptible to tears and fractures from these cavitation events, but limitations in existing characterization methods make it difficult to understand the relationship between fracture and cavitation in this tissue. More broadly, fracture energy is an important, yet often overlooked, mechanical property of all soft tissues. We combined needle-induced cavitation with hydraulic fracture models to induce and quantify fracture in intact brains at precise locations. We report here the first measurements of the fracture energy of intact brain tissue that range from 1.5 to 8.9 J/m, depending on the location in the brain and the model applied. We observed that fracture consistently occurs along interfaces between regions of brain tissue. These fractures along interfaces allow cavitation-related damage to propagate several millimeters away from the initial injury site. Quantifying the forces necessary to fracture brain and other soft tissues is critical for understanding how impact and blast waves damage tissue in vivo and has implications for the design of protective gear and tissue engineering.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382329PMC
http://dx.doi.org/10.1016/j.bpj.2022.06.016DOI Listing

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