AI Article Synopsis
- Myocardial ischemia/reperfusion (I/R) injury involves complex pathology, significantly influenced by oxidative stress.
- The study focuses on the role of ubiquitin-specific protease 7 (USP7) in regulating this injury through proteasome degradation and its connection to the Keap1 pathway, which responds to reactive oxygen species.
- Results show that increased USP7 expression during I/R contributes to heart damage, while its inhibition can reduce oxidative stress, cell death, and improve heart function, highlighting USP7's potential as a therapeutic target.
Article Abstract
Myocardial ischemia/reperfusion (I/R) injury is a complex pathological process that is still not fully understood. The oxidative stress response has a critical role in the occurrence and progression of myocardial ischemia/reperfusion injury. This study investigated the specific mechanism of ubiquitin-specific protease 7 (USP7) regulation of myocardial ischemia/reperfusion injury from the perspective of proteasome degradation and its relation with the Keap1 pathway, a vital regulator of cytoprotective responses to endogenous and exogenous stress induced by reactive oxygen species (ROS) and electrophiles. Our data indicated that USP7 expression is increased during myocardial ischemia/reperfusion injury in mice, while its inhibiting suppressed the generation of oxygen free radicals and myocardial cell apoptosis, reduced myocardial tissue damage, and improved heart function. Mechanistically, USP7 stabilizes Keap1 by regulating its ubiquitination. Taken together, these findings demonstrate the potential therapeutic effect of USP7 on myocardial ischemia/reperfusion injury.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203583 | PMC |
| http://dx.doi.org/10.1038/s41420-022-01086-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!