Background: Testicular tumor is one of the common solid tumors in young men. Testicular choriocarcinoma is a non-spermatogonial germ cell tumor, which is the rarest of all testicular cancers. Choriocarcinoma usually shows bleeding at the metastatic site, while gastrointestinal involvement is rare.
Methods: Here, we report a case of testicular choriocarcinoma with gastrointestinal bleeding as the first diagnosis and summarize the similar cases all over the world in recent 20 years.
Results: A 28-year-old male was treated with repeated melena for 2 months. No bleeding foci of the stomach, duodenum, colon, and rectum were found in endoscopy, and no bleeding foci of digestive tract was found in selective angiography, but a space occupying lesions of the lung, liver, and upper jejunum were found in chest and abdominal CT. Considering the possibility of a metastatic tumor and the ineffectiveness of medical treatment, the patient was converted to surgical treatment. The postoperative pathology was consistent with testicular choriocarcinoma. The patient received a chemotherapy regimen of paclitaxel, ifosfamide, and cisplatin. At present, the chemotherapy regimen is well tolerated.
Conclusions: The case report confirmed that even if we cannot find the logical relationship between clinical manifestations and genital examination, genital examination should also be part of the patient's systematic examination.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202100 | PMC |
| http://dx.doi.org/10.1186/s12957-022-02670-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[A Case of Intestinal Metastasis of Testicular Choriocarcinoma Revealed Through Gastrointestinal Bleeding].
Hinyokika Kiyo
November 2024
The Department of Urology, Hiroshima Prefectural Hospital.
A 26-year-old male presented to a hospital with complaints of hemoptysis and right scrotal swelling. Computed tomography (CT) revealed right testicular swelling, multiple lung metastases, and small intestinal wall thickening. The patient's β-human chorionic gonadotropin, alpha-fetoprotein, lactate dehydrogenase, and hemoglobin levels were 103.
View Article and Find Full Text PDFComparative analysis of testicular and nontesticular choriocarcinoma: a population-based study.
Ann Med Surg (Lond)
December 2024
Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Article Synopsis
- Germ cell tumors (GCTs), particularly choriocarcinoma, show differing characteristics and treatment outcomes based on their location, with testicular choriocarcinoma being more common and showing better survival rates than nontesticular forms.
- The study analyzed data from 363 patients diagnosed between 2000 and 2018, finding that 74.4% had testicular choriocarcinoma, with surgery being a common treatment for these patients, especially among white individuals.
- The results suggest the importance of tailored treatment approaches for different choriocarcinoma subtypes, highlight racial disparities in incidence, and indicate that while surgery improves outcomes, the role of chemotherapy and radiotherapy in
Human chorionic gonadotropin (hCG) has structural similarities with thyroid-stimulating hormone (TSH) and may stimulate TSH receptors at higher concentrations. During pregnancy, placental hCG causes TSH suppression, contributing to hyperemesis. However, in males, clinical manifestations caused by excess hCG are rare.
View Article and Find Full Text PDFStereotactic Radiosurgery for Choriocarcinoma Brain Metastases: Illustrative Case Presentation and Systematic Review.
World Neurosurg
November 2024
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA. Electronic address:
Background: Choriocarcinoma (CC) is a rare and aggressive form of germ cell tumor. There is limited evidence describing clinical outcomes in patients with primary CC and brain metastases (BM). Only a few single case reports have documented the use of stereotactic radiosurgery (SRS) for CC BM.
View Article and Find Full Text PDFEpithelioid trophoblastic tumor in male patients with germ cell tumor: A clinicopathologic analysis of five cases.
Hum Pathol
November 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:
Article Synopsis
- Epithelioid trophoblastic tumor (ETT) is a rare type of tumor found in the testis, with only seven cases documented before this study, which adds five more cases from a single institution, making it the largest series reported.
- The patients had a mean age of 44, and most had prior testicular germ cell tumors treated with chemotherapy; ETT appeared in metastatic sites many years later, and its diagnosis was often associated with unusual histological features that can resemble other types of cancer.
- Despite treatment, the outcomes were poor, with two patients dying within 17 months of diagnosis and three others remaining alive with metastatic disease averaging 20 months post-diagnosis, highlighting the aggressive nature of ETT.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!