Environ Int
School of Public Health, Wuhan University of Science and Technology, Wuhan, China; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China. Electronic address:
Published: July 2022
Background: Emerging evidence suggests that early-life (in-utero and first-year since birth) exposure to ambient PM is a risk factor for asthma onset and exacerbation among children, while the hazards caused by PM compositions remain largely unknown.
Objective: To examine potential associations of early-life exposures to PM mass and its major chemical constituents with childhood asthma and wheezing.
Methods: By conducting the Phase II of the China, Children, Homes, Health study, we investigated 30,325 preschool children aged 3-6 years during 2019-2020 in mainland China. Early-life exposure to PM mass and its constituents (i.e., black carbon [BC], organic matter [OM], nitrate, ammonium, sulfate) were calculated based on monthly estimates at a 1 km × 1 km resolution from satellite-based models. We adopted a novel quantile-based g-computation approach to assess the effect of a mixture of PM constituents on childhood asthma/wheezing.
Results: The average PM concentrations during in-utero and the first year since birth were 64.7 ± 10.6 and 61.8 ± 10.5 µg/m, respectively. Early-life exposures to a mixture of major PM constituents were significantly associated with increased risks of asthma and wheezing, while no evident compositions-wheezing associations were found in the first year. Each quintile increases in all five PM components exposures in utero was accordingly associated with an odds ratio of 1.18 [95% confidence interval: 1.07-1.29] for asthma and 1.08 [1.01-1.16] for wheezing. BC, OM and SO contributed more to risks of asthma and wheezing than the other PM constituents during early life, wherein the effects of BC were only observed during pregnancy. Sex subgroup analyses suggested stronger associations among girls of first-year exposures to PM components with childhood asthma.
Conclusion: Early-life exposures to ambient PM, particularly compositions of BC, OM and SO, are associated with an increased risk of childhood asthma.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.envint.2022.107297 | DOI Listing |
Cells
October 2024
Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. After birth and in adulthood, adipose tissue macrophages (ATMs) are relevant constituents of the fat depots, and they are necessary for physiological adipose tissue development and fat metabolism.
View Article and Find Full Text PDFBJPsych Open
November 2024
Mental Health and Clinical Neurosciences Unit, Institute of Mental Health, University of Nottingham, UK.
Background: Child and adolescent mental health service in-patient beds are unevenly spread throughout England. Where demand outstrips bed availability, young people may be admitted at-distance or to adult psychiatric wards. The COVID-19 pandemic added pressures to already overstretched services.
View Article and Find Full Text PDFNicotine Tob Res
October 2024
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Introduction: The influence of early exposure to sweet and fruit flavors on subsequent nicotine use behaviors during adolescence remains poorly understood. To address this gap, we utilized a rodent model to simulate childhood flavor exposure and examine its effects on later nicotine use behaviors.
Methods: We employed a two-bottle choice paradigm in weanling rats to mimic human childhood flavor exposure.
Vopr Pitan
October 2024
High Technology Park of Ugra, 628011, Khanty-Mansiysk, Russian Federation.
J Dent Res
November 2024
The Lion Foundation for Dental Health, Taito-ku, Tokyo, Japan.
Childhood is considered crucial in the establishment of future oral microbiota. However, the precise period of oral microbiota development remains unclear. This study aimed to identify the progression of oral microbiota formation in children.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.