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Spectroscopic investigation of proton bonding at sub-kelvin temperatures.
Phys Chem Chem Phys
January 2025
Center for Nanoscience and Sustainable Technologies (CNATS), Universidad Pablo de Olavide, 41013 Seville, Spain.
The proton bond is a pivotal chemical motif in many areas of science and technology. Its quantum chemical description is remarkably challenged by nuclear and charge delocalization effects and the fluxional perturbation that it induces on molecular substrates. This work seeks insights into proton bonding at sub-kelvin temperatures.
View Article and Find Full Text PDFStructural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop.
Front Chem Biol
August 2024
Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, Concordia University Wisconsin, Mequon, WI, United States.
Introduction: Dual specific phosphatases (DUSPs) are mitogen-activated protein kinase (MAPK) regulators, which also serve as drug targets for treating various vascular diseases. Previously, we have presented mechanistic characterizations of DUSP5 and its interaction with pERK, proposing a dual active site.
Methods: Herein, we characterize the interactions between the DUSP5 phosphatase domain and the pT-E-pY activation loop of ERK2, with specific active site assignments.
An Efficient Ultra-Narrowband Yellow Emitter Based on a Double-Boron-Embedded Tetraazacyclophane.
Angew Chem Int Ed Engl
January 2025
Nanjing University, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, 210023, Nanjing, CHINA.
Ultra-narrowband and highly modifiable multiple resonance thermally activated delayed fluorescence (MR-TADF) materials are crucial for realizing high-performance wide-color-gamut display applications. Despite progress, most MR-TADF emitters remain confined to blue and green wavelengths, with difficulties extending into longer wavelengths without significant spectral broadening, which compromises color purity in full-color organic light-emitting diode (OLED) displays. In this work, we present a novel tetraazacyclophane-based architecture embedding dual boron atoms to remarkedly enhance intramolecular charge transfer through the strategic positioning of boron and nitrogen atoms.
View Article and Find Full Text PDFTranscriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in .
Metabolites
December 2024
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Background: Aging and age-related diseases are closely linked to an imbalance in energy supply and demand, a condition that can potentially be mitigated through various interventions, including the use of naturally occurring molecules. Norathyriol (NL), a tetrahydroxyxanthone compound, is prevalent in mango fruit and medicinal plants. While studies have indicated that NL may influence metabolism, its effects on aging have not been extensively explored.
View Article and Find Full Text PDFThree-dimensional single-cell transcriptome imaging of thick tissues.
Elife
December 2024
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Center for Brain Science, Harvard University, Cambridge, United States.
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows genome-scale imaging of RNAs in individual cells in intact tissues. To date, MERFISH has been applied to image thin-tissue samples of ~10 µm thickness. Here, we present a thick-tissue three-dimensional (3D) MERFISH imaging method, which uses confocal microscopy for optical sectioning, deep learning for increasing imaging speed and quality, as well as sample preparation and imaging protocol optimized for thick samples.
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