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Head Neck
Department of Otolaryngology - Head and Neck Surgery, UT Southwestern Medical Center, Dallas, Texas, USA.
Published: October 2022
Background: The relative incidence of laryngeal cancer is rising in young patients, yet their characteristics, risk factors, and outcomes relative to older patients are poorly understood.
Methods: Retrospective cohort analysis of the National Cancer Database from 2006 to 2015.
Results: Among 25 029 total patients, 923 (3.7%) were young (<45 years old) and 3266 underwent tumor HPV testing. Compared to older patients, a greater proportion of young patients were female (30.3%, 23.3%; p < 0.001) and seen with high-risk HPV-positive tumors (29.9%, 12.4%; p < 0.001). In subset analyses of young patients, females with higher income (≥$38 000) exhibited a decreased risk of overall mortality compared to all other sex-income subcategories (adjusted hazard ratio [aHR]: 0.43, 95% confidence interval [CI]: 0.25-0.72). In subset analyses of patients of all ages with known tumor HPV status, patients with high-risk HPV-positive tumors exhibited a reduced risk of all-cause mortality (aHR: 0.74, 95%CI: 0.60-0.92, p = 0.007).
Conclusion: The interdependent associations between age, sex, tumor HPV status, and income on laryngeal cancer outcomes warrant further investigation.
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http://dx.doi.org/10.1002/hed.27120 | DOI Listing |
Braz J Psychiatry
March 2025
Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.
Objective: This study aimed to mine and analyze adverse event signals of fluoxetine using the FAERS database.
Methods: This study focused on suspected drug adverse reaction reports from the first quarter of 2004 to the second quarter of 2023, with fluoxetine as the primary suspected drug. Four signal mining and analysis methods were employed to comprehensively assess adverse event signals.
J Neurol
March 2025
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Background: Spinal muscular atrophy (SMA) is a motor neuron disease with loss of musculature, which is replaced by fat. Previous magnetic resonance imaging (MRI) studies have focused on imaging muscles either in lower or upper extremities, but whole-body MRI can provide additional information on the involvement pattern. This study examined whole-body muscle fat replacement and the relationship between muscle structure, function, and bulbar symptoms.
View Article and Find Full Text PDFPak J Pharm Sci
March 2025
Department of Plastic and Cosmetic Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
To compare the drug effects and adverse reactions of doxycycline and isotretinoin in patients with moderate to severe acne. A retrospective analysis was conducted on 98 patients with moderate to severe acne who were treated in the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from June 2020 to June 2023. They were divided into group A and group B based on actual medication use, with 49 cases in each group.
View Article and Find Full Text PDFObjective: To examine the accuracy of the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), the population-based clinical quality registry for people with kidney failure, in identifying Aboriginal and/or Torres Strait Islander people.
Design: Population-based cohort study of reporting accuracy.
Setting: New South Wales, 2006-2020.
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