AI Article Synopsis
- The study investigates the role of blood Th1, Th2, and Th17 cells and their cytokines in postpartum depression (PPD) and postpartum anxiety (PPA) among 226 women.
- Th17 cells and the cytokine IL-17A were found to be significantly associated with higher scores on depression and anxiety assessments, indicating a correlation with PPD and PPA.
- The findings suggest that increased levels of Th17 cells may independently raise the risk of developing PPD and PPA.
Article Abstract
Background: T-helper (Th) cells regulate inflammation and immunity, which is implicated in psychological disorders. The current study aimed to explore the clinical role of blood Th1, Th2, and Th17 cells and their main secreted cytokines in postpartum depression (PPD) and postpartum anxiety (PPA).
Methods: A total of 226 postpartum women were included. At 6 weeks postpartum, Edinburgh Postnatal Depression Scale (EPDS) and State Trait Anxiety Inventory 6 item version (STAI6) scores were assessed; meanwhile, blood Th1, Th2, and Th17 cells were detected by flow cytometry, serum interferon-gamma (IFN-γ), interleukin-4 (IL-4), and IL-17A were detected by enzyme-linked immunosorbent assay.
Results: The incidence of PPD and PPA were 24.3% and 27.9%, respectively. Th17 cells and IL-17A were positively correlated with EPDS score and STAI6 score (all p < 0.001). Besides, Th17 cells (p < 0.001) and IL-17A (p = 0.002) were increased in PPD cases vs. non-PPD cases, and they were also elevated in PPA cases vs. non-PPA cases (both p < 0.05). However, Th1 cells, Th2 cells, IFN-γ, and IL-4 were not linked with EPDS score or STAI6 score (all p > 0.05); besides, they did not vary in PPD cases vs. non-PPD cases or in PPA cases vs. non-PPA cases (all p > 0.05). Multivariate logistic regression model analysis showed that Th17 cells were independently associated with an elevated risk of PPD (odds ratio [OR] = 1.600, p = 0.001) and PPA (OR = 1.371, p = 0.022).
Conclusion: Blood Th17 cells and IL-17A are positively linked with the risk of PPD and PPA, indicating which may be involved in the development of PPD and PPA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279994 | PMC |
| http://dx.doi.org/10.1002/jcla.24559 | DOI Listing |
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