AI Article Synopsis
- FPR2 agonists have shown potential in treating diseases related to inflammation based on successful animal studies.
- Many synthetic agonists include a phenylurea component, which is crucial for their effectiveness, leading researchers to explore alternative structures, or isosteres.
- The study reveals the discovery of new FPR2 agonists, specifically benzimidazole and aminophenyloxadiazole compounds, that exhibit strong activity at low nanomolar concentrations.
Article Abstract
Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to be necessary for activity in the reported chemotypes. We set out to find isosteres for the phenylurea and focused our efforts on heteroaryl rings. The wide range of potencies with heterocyclic isosteres demonstrates how electronic effects of the heteroatom placement impact molecular recognition. Herein, we report our discovery of benzimidazole and aminophenyloxadiazole FPR2 agonists with low nanomolar activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190041 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.2c00079 | DOI Listing |
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