The four-parameter kappa distribution (K4D) is a generalized form of some commonly used distributions such as generalized logistic, generalized Pareto, generalized Gumbel, and generalized extreme value (GEV) distributions. Owing to its flexibility, the K4D is widely applied in modeling in several fields such as hydrology and climatic change. For the estimation of the four parameters, the maximum likelihood approach and the method of L-moments are usually employed. The L-moment estimator (LME) method works well for some parameter spaces, with up to a moderate sample size, but it is sometimes not feasible in terms of computing the appropriate estimates. Meanwhile, using the maximum likelihood estimator (MLE) with small sample sizes shows substantially poor performance in terms of a large variance of the estimator. We therefore propose a maximum penalized likelihood estimation (MPLE) of K4D by adjusting the existing penalty functions that restrict the parameter space. Eighteen combinations of penalties for two shape parameters are considered and compared. The MPLE retains modeling flexibility and large sample optimality while also improving on small sample properties. The properties of the proposed estimator are verified through a Monte Carlo simulation, and an application case is demonstrated taking Thailand's annual maximum temperature data.
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http://dx.doi.org/10.1080/02664763.2021.1871592 | DOI Listing |
Radiography (Lond)
December 2024
Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address:
Introduction: Optimizing the image quality of Positron Emission Tomography/Computed Tomography (PET/CT) systems is crucial for effective monitoring, diagnosis, and treatment planning in oncology. This study evaluates the impact of time-of-flight (TOF) on PET/CT performance, focusing on varying penalty β values within Q. Clear reconstruction algorithm.
View Article and Find Full Text PDFArch Orthop Trauma Surg
December 2024
Department of Surgery, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Background: Nosocomial pneumonia is common in trauma patients and associated with an adverse prognosis. We recently externally validated and recalibrated an existing formula to predict nosocomial pneumonia risk. Identifying more potential predictors could aid in a more accurate prediction of nosocomial pneumonia risk in level-1 trauma patients.
View Article and Find Full Text PDFAm J Hum Genet
January 2025
Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Exploring the molecular correlates of metabolic health measures may identify their shared and unique biological processes and pathways. Molecular proxies of these traits may also provide a more objective approach to their measurement. Here, DNA methylation (DNAm) data were used in epigenome-wide association studies (EWASs) and for training epigenetic scores (EpiScores) of six metabolic traits: body mass index (BMI), body fat percentage, waist-hip ratio, and blood-based measures of glucose, high-density lipoprotein cholesterol, and total cholesterol in >17,000 volunteers from the Generation Scotland (GS) cohort.
View Article and Find Full Text PDFStroke
December 2024
Departments of Neurology, Amsterdam UMC location University of Amsterdam, the Netherlands. (S.S.N., L.A.R., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.).
Background: Cardiac computed tomography (CT) is increasingly used to search for cardioembolic sources of acute ischemic stroke (AIS). We assessed the association between high-risk cardioembolic sources on cardiac CT and AIS.
Methods: We performed a case-control study using data from a prospective cohort including consecutive adult patients with suspected stroke who underwent cardiac CT acquired during the initial stroke imaging protocol between 2018 and 2020.
BMC Med Inform Decis Mak
December 2024
Division of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest University School of Medicine, 525 Vine St, Winston-Salem, NC, 27101, USA.
Background: A prediction model that estimates the risk of elevated glycated hemoglobin (HbA1c) was developed from electronic health record (EHR) data to identify adult patients at risk for prediabetes who may otherwise go undetected. We aimed to assess the internal performance of a new penalized regression model using the same EHR data and compare it to the previously developed stepdown approximation for predicting HbA1c ≥ 5.7%, the cut-off for prediabetes.
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