For count responses, there are situations in biomedical and sociological applications in which extra zeroes occur. Modeling correlated (e.g. repeated measures and clustered) zero-inflated count data includes special challenges because the correlation between measurements for a subject or a cluster needs to be taken into account. Moreover, zero-inflated count data are often faced with over/under dispersion problem. In this paper, we propose a random effect model for repeated measurements or clustered data with over/under dispersed response called random effect zero-inflated exponentiated-exponential geometric regression model. The proposed method was illustrated through real examples. The performance of the model and asymptotical properties of the estimations were investigated using simulation studies.
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http://dx.doi.org/10.1080/02664763.2019.1706726 | DOI Listing |
BMC Bioinformatics
January 2025
Centre for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
Background: With the advance of next-generation sequencing, various gene-based rare variant association tests have been developed, particularly for binary and continuous phenotypes. In contrast, fewer methods are available for traits not following binomial or normal distributions. To address this, we previously proposed a set of burden- and kernel-based rare variant tests for count data following zero-inflated Poisson (ZIP) distributions, referred to as ZIP-b and ZIP-k tests.
View Article and Find Full Text PDFJ Am Heart Assoc
January 2025
Background: Left ventricular (LV) geometric patterns are associated with cognitive impairment and cerebral small vessel disease. As a novel magnetic resonance imaging marker of cerebral small vessel disease and a risk factor for cognitive dysfunction, cortical cerebral microinfarcts (CMIs) have been associated with heart disease through mechanisms including cardioembolism and cerebral hypoperfusion. Further investigation is required to determine whether cortical CMIs could arise from hemodynamic changes related to LV geometry, thus elucidating the connection between LV geometry and cognitive function.
View Article and Find Full Text PDFPNAS Nexus
January 2025
Chair of Systems Design, ETH Zurich, Weinbergstrasse 56/58, Zurich 8092, Switzerland.
Real-world networks are sparse. As we show in this article, even when a large number of interactions is observed, most node pairs remain disconnected. We demonstrate that classical multiedge network models, such as the , configuration models, and stochastic block models, fail to accurately capture this phenomenon.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Quantitative Methods, School of Business, King Faisal University, Al-Ahsa, Saudi Arabia.
Accurate forecasting of claim frequency in automobile insurance is essential for insurers to assess risks effectively and establish appropriate pricing policies. Traditional methods typically rely on a Poisson distribution for modeling claim counts; however, this approach can be inadequate due to frequent zero-claim periods, leading to zero inflation in the data. Zero inflation occurs when more zeros are observed than expected under standard Poisson or negative binomial (NB) models.
View Article and Find Full Text PDFFront Public Health
December 2024
Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Purpose: This study investigates the determinants of smoking behavior among young adults in Khuzestan province, southwest Iran, using two-level count regression models. Given the high prevalence of smoking-related diseases and the social impact of smoking, understanding the factors influencing smoking habits is crucial for effective public health interventions.
Methods: We conducted a cross-sectional analysis of 1,973 individuals aged 18-35 years, using data from the Daily Smoking Consumption Survey (DSCS) in Khuzestan province collected in 2023.
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