Simultaneous confidence interval construction for many-to-one comparisons of proportion differences based on correlated paired data.

J Appl Stat

Department of Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.

Published: July 2020

In some medical researches such as ophthalmological, orthopaedic and otolaryngologic studies, it is often of interest to compare multiple groups with a control using data collected from paired organs of patients. The major difficulty in performing the data analysis is to adjust the multiplicity between the comparison of multiple groups, and the correlation within the same patient's paired organs. In this article, we construct asymptotic (SCIs) for many-to-one comparisons of proportion differences adjusting for multiplicity and the correlation. The coverage probabilities and widths of the proposed CIs are evaluated by Monte Carlo simulation studies. The methods are illustrated by a real data example.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042020PMC
http://dx.doi.org/10.1080/02664763.2020.1795815DOI Listing

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