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| http://dx.doi.org/10.1007/s00109-022-02217-z | DOI Listing |
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Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion.
Tissue Eng Regen Med
August 2024
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands.
Background: The extracellular vesicles (EVs) secreted by adipose tissue-derived stromal cells (ASC) are microenvironment modulators in tissue regeneration by releasing their molecular cargo, including miRNAs. However, the influence of ASC-derived extracellular vesicles (ASC-EVs) on endothelial cells (ECs) and vascularisation is poorly understood. The present study aimed to determine the pro-angiogenic effects of ASC-EVs and explore their miRNA profile.
View Article and Find Full Text PDFAn Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses.
ACS Nano
October 2023
Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai City, Miyagi 980-8578, Japan.
RNA vaccines based on lipid nanoparticles (LNPs) with transcribed mRNA (IVT-mRNA) encapsulated are now a currently successful but still evolving modality of vaccines. One of the advantages of RNA vaccines is their ability to induce CD8 T-cell-mediated cellular immunity that is indispensable for excluding pathogen-infected cells or cancer cells from the body. In this study, we report on the development of LNPs with an enhanced capability for inducing cellular immunity by using an ionizable lipid with a vitamin E scaffold.
View Article and Find Full Text PDFThe scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis.
J Mol Med (Berl)
July 2022
Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, Inserm, Paris, France.
The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis.
Mucosal Immunol
January 2022
Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
Receptor interacting protein kinase 1 (RIPK1) is a cytosolic multidomain protein that controls cell life and death. While RIPK1 promotes cell death through its kinase activity, it also functions as a scaffold protein to promote cell survival by inhibiting FADD-caspase 8-dependent apoptosis and RIPK3-MLKL-dependent necroptosis. This pro-survival function is highlighted by excess cell death and perinatal lethality in Ripk1 mice.
View Article and Find Full Text PDFScaffold-Dependent Mechanical and Architectural Cues Guide Osteochondral Defect Healing .
Front Bioeng Biotechnol
February 2021
Julius Wolff Institute, Charité Universitaetsmedizin Berlin, Berlin, Germany.
Osteochondral defects in joints require surgical intervention to relieve pain and restore function. However, no current treatment enables a complete reconstitution of the articular surface. It is known that both mechanical and biological factors play a key role on osteochondral defect healing, however the underlying principles and how they can be used in the design of treatment strategies remain largely unknown.
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