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The serotonergic psychedelic DOI impairs deviance detection in the auditory cortex.
J Neurophysiol
December 2024
Institute of Neuroscience, University of Oregon. Eugene, OR 97403.
Psychedelics are known to induce profound perceptual distortions, yet the neural mechanisms underlying these effects, particularly within the auditory system, remain poorly understood. In this study, we investigated the effects of the psychedelic compound 2,5-Dimethoxy-4-iodoamphetamine (DOI), a serotonin 2A receptor agonist, on the activity of neurons in the auditory cortex of awake mice. We examined whether DOI administration alters sound-frequency tuning, variability in neural responses, and deviance detection (a neural process reflecting the balance between top-down and bottom-up processing).
View Article and Find Full Text PDFAcute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants.
Neuropsychopharmacology
December 2024
Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that is known for its short-lasting effects when administered intravenously. Several studies have investigated the administration of intravenous boluses or combinations of a bolus and a subsequent continuous infusion. However, data on dose-dependent acute effects and pharmacokinetics of continuous DMT infusions are lacking.
View Article and Find Full Text PDFDivergent Effects of Ketamine and the Serotoninergic Psychedelic 2,5-Dimethoxy-4-Iodoamphetamine on Hippocampal Plasticity and Metaplasticity.
Psychedelic Med (New Rochelle)
September 2024
Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53706.
Introduction: Serotonergic psychedelics and ketamine produce rapid and long-lasting symptomatic relief in multiple psychiatric disorders. Evidence suggests that despite having distinct molecular targets, both drugs may exert therapeutic benefit via their pro-neuroplastic effects. Following treatment with ketamine or serotonergic psychedelics, patients are reported to be more open to behavioral change, which is leveraged for psychotherapy-assisted reframing of narratives of the self.
View Article and Find Full Text PDFSynergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.
Transl Psychiatry
December 2024
Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK.
Article Synopsis
- Serotonergic psychedelics, like LSD and psilocybin, alter consciousness and may help treat mental health issues, but how they work is still not entirely clear.
- The study reviews subjective experiences, neuroimaging, and molecular actions, indicating LSD leads to more intense visionary experiences compared to psilocybin and alters brain connectivity patterns.
- Findings suggest a complex relationship between different psychedelics' effects and highlight the need for standardized research methods to better understand these substances and their therapeutic potential.*
How to Make Psychedelic-Assisted Therapy Safer.
Camb Q Healthc Ethics
December 2024
Uehiro Oxford Institute, University of Oxford, Oxford, UK.
Classic serotonergic psychedelics are experiencing a clinical revival, which has also revived ethical debates about psychedelic-assisted therapy. A particular issue here is how to prepare and protect patients from the vulnerability that the psychedelic state creates. This article first examines how this vulnerability manifests itself, revealing that it results from an impairment of autonomy: psychedelics diminish decision-making capacity, reduce controllability, and limit resistance to external influences.
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