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| http://dx.doi.org/10.1016/j.stemcr.2022.05.007 | DOI Listing |
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Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep.
Commun Biol
January 2025
Chinese Institute of Brain Research, Beijing (CIBR), and Chinese Institutes for Medical Research, Beijing (CIMR), Capital Medical University, Beijing, China.
While sleep is important, our understanding of its molecular mechanisms is limited. Over the last two decades, protein kinases including Ca/calmodulin-dependent protein kinase II (CaMKII) α and β have been implicated in sleep regulation. Of all the known mouse genetic mutants, the biggest changes in sleep is reported to be observed in adult mice with sgRNAs for Camk2b injected into their embryos: sleep is reduced by approximately 120 min (mins) over 24 h (hrs).
View Article and Find Full Text PDFCortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis.
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January 2025
Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Sleep deprivation is a common public problem, and researchers speculated its neurophysiological mechanisms related to cortical excitatory and inhibitory activity. Recently, transcranial magnetic stimulation combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) have been used to assess cortical excitability in sleep-deprived individuals, but the results were inconsistent. Therefore, we conducted a meta-analysis to summarize relevant TMS-evoked indices of excitability and inhibition for exploring the cortical effects of sleep deprivation.
View Article and Find Full Text PDFSleep deprivation and corneal chronobiology: reevaluating overnight corneal changes.
Sci Rep
January 2025
Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei blvd. 98, Debrecen, 4012, Hungary.
This prospective cohort study is aimed to investigate circadian variations in corneal parameters, focusing on sleep-deprived subjects. Sixty-four healthy individuals (age range: 21-76 years) actively participated in this study, undergoing examinations at least five times within a 24-hour timeframe. The analysis encompassed keratometric parameters of the cornea's front (F) and back (B) surfaces, refractive power in flattest and steepest axes (K1, K2), astigmatism (Astig) and its axis (Axis), aspheric coefficient (Asph), corneal pachymetry values of thinnest corneal thickness (Pachy Min) and corneal thickness in the center of the pupil (Pachy Pupil), volume relative to the 3 and 10 mm corneal diagonal (Vol D3, Vol D10) and surface variance index (ISV).
View Article and Find Full Text PDFSleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.
Biomed J
January 2025
Department of Anesthesiology, Perioperative and Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450000, China; Henan Province International Joint Laboratory of Pain, Cognition and Emotion, Zhengzhou, Henan Province 450000, China. Electronic address:
Sleep is crucial for sustaining normal physiological functions, and sleep deprivation has been associated with increased pain sensitivity. The histone deacetylases (HDACs) are known to significantly regulate in regulating neuropathic pain, but their involvement in nociceptive hypersensitivity during sleep deprivation is still not fully understood. Utilizing a modified multi-platform water environment technique to establish a sleep deprivation model.
View Article and Find Full Text PDFAssociations Between Sleep Duration and Lifestyle Risk Factors Among Adolescents: A Cross-Sectional Study.
Am J Health Promot
January 2025
Department of Health Management and Policy, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO, USA.
Purpose: Examining the associations between sleep duration and lifestyle risk factors and assessed whether sex modify such associations among U.S. adolescents.
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