AI Article Synopsis
- Quadruplexes are unique 3D structures in nucleic acids that are difficult to visualize and analyze using standard bioinformatics methods, often leading to the use of hand-drawn diagrams.
- DrawTetrado is a new open-source Python program designed to automate the visualization of quadruplexes and G4-helices, producing customizable static layer diagrams with a pseudo-3D effect.
- The program is freely available under the MIT license on GitHub, allowing easy access for researchers interested in nucleic acid structure visualization.
Article Abstract
Motivation: Quadruplexes are specific 3D structures found in nucleic acids. Due to the exceptional properties of these motifs, their exploration with the general-purpose bioinformatics methods can be problematic or insufficient. The same applies to visualizing their structure. A hand-drawn layer diagram is the most common way to represent the quadruplex anatomy. No molecular visualization software generates such a structural model based on atomic coordinates.
Results: DrawTetrado is an open-source Python program for automated visualization targeting the structures of quadruplexes and G4-helices. It generates static layer diagrams that represent structural data in a pseudo-3D perspective. The possibility to set color schemes, nucleotide labels, inter-element distances or angle of view allows for easy customization of the output drawing.
Availability And Implementation: The program is available under the MIT license at https://github.com/RNApolis/drawtetrado.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344840 | PMC |
| http://dx.doi.org/10.1093/bioinformatics/btac394 | DOI Listing |
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