AI Article Synopsis
- - The study aimed to evaluate changes in corneal thickness (pachymetry) after a new epithelium-on crosslinking (CXL) procedure called EpiSmart.
- - A total of 101 eyes were analyzed at multiple time points (baseline, 3, 6, and 12 months post-CXL), showing no significant changes in thickness with measurements remaining stable around 450 microns throughout the study.
- - The conclusion indicated that the EpiSmart CXL procedure did not result in significant corneal thinning over a year, as confirmed by the measurements taken.
Article Abstract
Purpose: To assess the change in corneal pachymetry after a novel epithelium-on (EpiSmart) corneal crosslinking procedure (CXL).
Methods: Eyes treated as part of the open-label, non-controlled arm of the study "Collagen Crosslinking with Ultraviolet-A in Asymmetric Corneas" (NCT01097447) were examined at baseline, 3-, 6- and 12-months post-CXL. Thinnest pachymetry readings based on Pentacam (OCULUS GmbH, Wetzlar, Germany) were recorded.
Results: A total of 101 eyes met the study inclusion criteria. Thinnest pachymetric readings at baseline averaged 451 ± 50 microns. The mean (± SD) minimum thickness was 450 ± 46 microns at 3 months, 452 ± 47 microns at 6 months, and 451 ± 48 microns at 12 months post-CXL. The changes from baseline (mean ± SE) at 3, 6, and 12 months post-CXL were -1.2 ± 1.5 microns, 0.5 ± 1.6 microns, and 0.4 ± 1.6 microns, respectively. Student's t-tests showed no statistically significant change in pachymetry from baseline for any exam period.
Conclusion: This study demonstrated that, after EpiSmart epithelium-on CXL, there was no substantial corneal thinning observable on Scheimpflug tomography out to 12 months.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188777 | PMC |
| http://dx.doi.org/10.2147/OPTH.S359710 | DOI Listing |
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