AI Article Synopsis
- The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has created a multigene panel called TruRisk® to identify risk genes related to familial breast and ovarian cancer.
- An expert team analyzed existing research on how pathogenic mutations affect cancer risk using a structured literature review and a formal consensus process.
- The project's aim is to improve individual risk assessments and establish clinical recommendations for patient counseling and care, guiding them from the initial consultation through preventive or therapeutic options.
Article Abstract
Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer.
Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process.
Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149395 | PMC |
| http://dx.doi.org/10.1159/000516376 | DOI Listing |
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