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Growth rate determines prokaryote-provirus network modulated by temperature and host genetic traits. | LitMetric

Growth rate determines prokaryote-provirus network modulated by temperature and host genetic traits.

Microbiome

Key Laboratory of Biometallurgy of Ministry of Education, School of Minerals Processing and Bioengineering, Central South University, Changsha, 410006, China.

Published: June 2022

AI Article Synopsis

  • This study investigates how various life history traits, particularly the growth rate of prokaryotic hosts, influence their interactions with viruses, with a dataset of 7656 species-level genomes from 39 prokaryotic phyla across diverse environments.
  • It was found that faster-growing hosts (indicated by shorter doubling times) tend to have less specialized interactions with their viruses, and this relationship varies depending on the optimal growth temperature of the host species.
  • The findings suggest that factors like temperature and certain genetic traits can impact the dynamics of prokaryote-virus interactions, enhancing our understanding of these relationships during viral infection cycles.

Article Abstract

Background: Prokaryote-virus interactions play key roles in driving biogeochemical cycles. However, little is known about the drivers shaping their interaction network structures, especially from the host features. Here, we compiled 7656 species-level genomes in 39 prokaryotic phyla across environments globally and explored how their interaction specialization is constrained by host life history traits, such as growth rate.

Results: We first reported that host growth rate indicated by the reverse of minimal doubling time was negatively related to interaction specialization for host in host-provirus network across various ecosystems and taxonomy groups. Such a negative linear growth rate-specialization relationship (GrSR) was dependent on host optimal growth temperature (OGT), and stronger toward the two gradient ends of OGT. For instance, prokaryotic species with an OGT ≥ 40 °C showed a stronger GrSR (Pearson's r = -0.525, P < 0.001). Significant GrSRs were observed with the presences of host genes in promoting the infection cycle at stages of adsorption, establishment, and viral release, but nonsignificant with the presence of immune systems, such as restriction-modification systems and CRISPR-Cas systems. Moreover, GrSR strength was increased with the presence of temperature-dependent lytic switches, which was also confirmed by mathematical modeling.

Conclusions: Together, our results advance our understanding of the interactions between prokaryotes and proviruses and highlight the importance of host growth rate in interaction specialization during lysogenization. Video Abstract.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195381PMC
http://dx.doi.org/10.1186/s40168-022-01288-xDOI Listing

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