AI Article Synopsis
- The study aimed to examine the relationship between specific genes and the effectiveness of risperidone treatment in a Chinese patient group.
- A total of 148 patients were tested, with a focus on three single nucleotide polymorphisms (SNPs) through advanced genotyping technology.
- Results showed that SNPs rs7627954 and rs2088885 were significantly linked to treatment response, indicating that certain genetic variations may influence how well individuals respond to risperidone.
Article Abstract
To investigate whether the gene affects risperidone treatment outcomes in the Chinese population. A total of 148 unrelated inpatients who received risperidone for six weeks were enrolled. The selected single nucleotide polymorphisms (SNPs; rs2088885, rs7627954 and rs13065441) were genotyped using the MassARRAY SNP IPLEX platform. The analysis showed that one novel SNP of , rs7627954, had a significant association with the response to risperidone (χ = 4.472; p = 0.034). This work also identified rs2088885 as significantly associated with risperidone response (χ = 5.257; p = 0.022). The result revealed that the rs2088885-rs7627954 C-T haplotype was more prevalent in good responders than in poor responders (p = 0.0278). This study revealed that the rs2088885 and rs7627954 SNPs of are associated with risperidone treatment response.
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| http://dx.doi.org/10.2217/pgs-2022-0052 | DOI Listing |
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