Injectable hydrogels exhibiting self-healing ability are promising carriers for controlled and sustained delivery in a minimally-invasive format for biomedical applications. We designed a polysaccharide-based double network hydrogel by mixing solutions of aldehyde-alginate (aAlg) and acrylic acid-chitosan (aCS) in the presence of adipic acid dihydrazide and FeCl that resulted in dual crosslinking mediated by Schiff base and ionic interactions. The hydrogel exhibited excellent thixotropic and self-healing properties with a high compressive fracture strength of ≈ 48 kPa. Encapsulated cells were viable within the hydrogel, and after their release from the degraded gel. The controlled release of Doxorubicin and Ciprofloxacin from the hydrogels established the gel as a delivery platform. The released drugs were effective in killing cancer cells or arresting the growth of both bacteria. This work presents a self-healing and injectable degradable hydrogel that may be used as a minimally-invasive platform for the delivery of drugs and cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2022.119585 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD.
J Exp Clin Cancer Res
January 2025
Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. CD4 or CD8 conventional T (Tconv) cells are critically involved in mediating anti-leukemic immune responses to prevent relapse and detrimental GvHD.
View Article and Find Full Text PDFResearch on predicting radiographic exposure time in imaging based on neural network prediction models.
Clin Neurol Neurosurg
January 2025
The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address:
Objective: To explore the anatomical and clinical factors that affect the radiographic exposure time in radial artery cerebral angiography and to establish a model.
Method: A total of 210 patients who underwent radial artery cerebral angiography at this center from September 2021 to May 2022 were selected, and their anatomical and clinical factors were analyzed to evaluate the correlation between these factors and the duration of radiographic exposure. A related neural network prediction model was established.
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.
Proc Natl Acad Sci U S A
February 2025
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock-in mice with PINK1 knock-out (KO) mice and report that loss of PINK1 does not impact endogenous LRRK2-mediated Rab phosphorylation nor do we see significant effect of mutant LRRK2 on PINK1-mediated Rab and Ub phosphorylation.
View Article and Find Full Text PDFMeasurement of multidifferential cross sections for dijet production in proton-proton collisions at .
Eur Phys J C Part Fields
January 2025
A measurement of the dijet production cross section is reported based on proton-proton collision data collected in 2016 at by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 . Jets are reconstructed with the anti- algorithm for distance parameters of and 0.
View Article and Find Full Text PDFBioinspired Conductivity-Enhanced, Self-Healing, and Renewable Silk Fibroin Hydrogel for Wearable Sensors with High Sensitivity.
ACS Appl Mater Interfaces
January 2025
Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuxiang Road 26, Shijiazhuang 050080, PR China.
The development of silk fibroin-based hydrogels with excellent biocompatibility, aqueous processability, and facile controllability in structure is indeed an exciting advancement for biological research and strain sensor applications. However, silk fibroin-based hydrogel strain sensors that combine high conductivity, high stretchability, reusability, and high selectivity are still desired. Herein, we report a simple method for preparing double-network hydrogels including silk fibroin and poly(acrylic acid) sodium-polyacrylate (PAA-PAAS) networks.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!