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Background: Depression has a multitude of clinical and public health consequences for HIV patients. The magnitude of HIV patients who failed first-line antiretroviral treatment and switched to second-line therapy is becoming a growing public health concern. However, unlike first-line therapy, to date, little attention has been given to mental health problems in such patients, particularly in the era of the COVID-19 pandemic. Thus, this research was conducted to determine the magnitude of depression and its determinants among HIV patients on second-line antiretroviral therapy.
Methods: A multi-centered cross-sectional study was conducted on 714 HIV patients on second-line therapy who were selected via systematic random sampling. Data were collected in personal interviews as well as document reviews. The nine-item patient health questionnaire score was used to assess depression, while the three-item Oslo Scale was used to assess social support. The associations between exogenous, mediating, and endogenous variables were identified simultaneously using structural equation modeling. Statistical significance was declared at a P-value less than 0.05, and the effect sizes were presented using 95% CI.
Results: Depression was reported in 27.7% of HIV patients on second-line therapy [95% CI: 24.7-31.1%]. Social support has a direct [[Formula: see text] = - 0.9, (95% CI: - 1.11 to - 0.69)] and indirect [[Formula: see text] = - 0.22, (95% CI: - 0.31 to - 0.13)] negative effect on depression. Perceived stigma was a mediator variable and significantly associated with depression [[Formula: see text] = 0.40, (95% CI: 0.23-0.57)]. Co-morbid illness [[Formula: see text] = 0.49, (95% CI: 0.35-0.63)], high viremia [[Formula: see text] = 0.17, (95% CI: 0.08-0.26], moderate and high-risk substance use [[Formula: see text] = 0.29, (95% CI: 0.18-0.39)], and not-workable functional status [[Formula: see text] = 0.2, (95% CI: 0.1-0.31)] were all positively associated with depression.
Conclusions: This study revealed that there was a high prevalence of depression among HIV patients on second-line antiretroviral therapy. Social and clinical factors were associated with depression risk. As a result, screening, prevention, and control strategies, including psychosocial support, should be strengthened in routine clinical care.
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http://dx.doi.org/10.1186/s13033-022-00536-9 | DOI Listing |
Philos Trans A Math Phys Eng Sci
December 2024
Max-Planck-Institut für die Physik des Lichts, Erlangen 91058, Germany.
We derive a compact expression for the second-order correlation function [Formula: see text] of a quantum state in terms of its Wigner function, thereby establishing a direct link between [Formula: see text] and the state's shape in phase space. We conduct an experiment that simultaneously measures [Formula: see text] through direct photocounting and reconstructs the Wigner function via homodyne tomography. The results confirm our theoretical predictions.
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December 2024
Information Technology Department, Faculty of Computers and Information, Mansoura University, Mansoura, 35516, Egypt.
The rice plant is one of the most significant crops in the world, and it suffers from various diseases. The traditional methods for rice disease detection are complex and time-consuming, mainly depending on the expert's experience. The explosive growth in image processing, computer vision, and deep learning techniques provides effective and innovative agriculture solutions for automatically detecting and classifying these diseases.
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December 2024
Department of Physics, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
This manuscript explores the stability theory of several stochastic/random models. It delves into analyzing the stability of equilibrium states in systems influenced by standard Brownian motion and exhibit random variable coefficients. By constructing appropriate Lyapunov functions, various types of stability are identified, each associated with distinct stability conditions.
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January 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Job loss is a common and disruptive life event. It is known to have numerous long-term negative effects on financial, health, and social outcomes. While the negative effects of becoming unemployed on health and well-being are well understood, the influence of job loss on financial decisions has received little attention.
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December 2024
Department of Electrical and Electronic Engineering, Imperial College London, London, SW7 2AZ UK.
RMSProp is one of the most popular stochastic optimization algorithms in deep learning applications. However, recent work has pointed out that this method may not converge to the optimal solution even in simple convex settings. To this end, we propose a time-varying version of RMSProp to fix the non-convergence issues.
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