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A Software Tool for Rapid and Automated Preprocessing of Large-Scale Serum Metabolomic Data by Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry.
Anal Chem
December 2024
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada.
Mass spectrometry (MS)-based metabolomics often rely on separation techniques when analyzing complex biological specimens to improve method resolution, metabolome coverage, quantitative performance, and/or unknown identification. However, low sample throughput and complicated data preprocessing procedures remain major barriers to affordable metabolomic studies that are scalable to large populations. Herein, we introduce PeakMeister as a new software tool in the R statistical environment to enable standardized processing of serum metabolomic data acquired by multisegment injection-capillary electrophoresis-mass spectrometry (MSI-CE-MS), a high-throughput separation platform (<4 min/sample) which takes advantage of a serial injection format of 13 samples within a single analytical run.
View Article and Find Full Text PDFCorrection: Mallphanov et al. Novel Approach to Increasing the Amplitude of the Mechanical Oscillations of Self-Oscillating Gels: Introduction of Catalysts Both as Pendant Groups and as Crosslinkers. 2024, , 727.
Gels
December 2024
Center for Nonlinear Chemistry, Immanuel Kant Baltic Federal University, 14 A. Nevskogo Street, Kaliningrad 236016, Russia.
In the original publication [...
View Article and Find Full Text PDFPolarization-resolved transmission matrices of specialty optical fibers.
Rev Sci Instrum
December 2024
OFS Laboratories, 19 Schoolhouse Road, Somerset, New Jersey 08873, USA.
Transmission matrix measurements of multimode fibers are now routinely performed in numerous laboratories, enabling control of the electric field at the distal end of the fiber and paving the way for the potential application to ultrathin medical endoscopes with high resolution. The same concepts are applicable to other areas, such as space division multiplexing, targeted power delivery, fiber laser performance, and the general study of the mode coupling properties of the fiber. However, the process of building an experimental setup and developing the supporting code to measure the fiber's transmission matrix remains challenging and time consuming, with full details on experimental design, data collection, and supporting algorithms spread over multiple papers or lacking in detail.
View Article and Find Full Text PDFElastic-plastic fracture analysis of pressure pipelines with axial cracks based on the interaction integral method.
PLoS One
December 2024
School of Mechanical Science and Engineering, Northeast Petroleum University, Daqing, Heilongjiang, China.
The proposed work aims to demonstrate the significance of the plastic zone at the tip of an axial crack in a pipeline for managing Stress IntensityFactors(SIF). The three-dimensional finite element model of pressure pipeline with axial cracks was built by utilizing the Ramberg-Osgood X80 material model of pipeline. according to Von Mises yield criterion, the size of plastic zone at crack tip was determined, and the fracture parameters were calculated based on interaction integral method, the plastic stress deformation law, determination of elastic-plastic limit load and plastic correction of SIF at crack tip of pressure pipeline with axial crack were discussed.
View Article and Find Full Text PDFNovel concept for the healthy population influencing factors.
Front Public Health
December 2024
School of Management Engineering and Business, Hebei University of Engineering, Handan, China.
In the rapid urbanization process in China, due to reasons such as employment, education, and family reunification, the number of mobile population without registered residence in the local area has increased significantly. By 2020, the group had a population of 276 million, accounting for over 20% of the total population, making significant contributions to urban economic development and resource optimization. However, the health status of migrant populations is affected by unique issues such as occupational risks and socio-economic disparities, which play an important role in personal welfare, social stability, and sustainable economic growth.
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