AI Article Synopsis
- Thermogenic fat has the ability to clear macronutrients from the bloodstream and convert them into heat, which helps regulate levels of glucose, lipids, and branched-chain amino acids (BCAA).
- This process increases energy expenditure and provides protection against diseases related to metabolism and the heart.
- Recent research has improved our understanding of how thermogenic fat takes in and processes these energy sources, focusing on the molecular and cellular mechanisms involved.
Article Abstract
Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain amino acids (BCAA) circulatory levels. At the same time, its activity yields a higher energy expenditure, thereby conferring protection against cardiometabolic diseases. Our knowledge on the mechanisms of uptake and intracellular metabolism of such energy substrates into thermogenic fat has meaningfully evolved in recent years. This has allowed us to better understand how the thermogenic machinery processes those molecules to utilize them as substrates for heating up the body. Here, we discuss recent advances in the molecular and cellular regulatory process that governs the uptake and metabolism of such substrates within thermogenic fat.
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| http://dx.doi.org/10.1016/j.tem.2022.05.003 | DOI Listing |
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