AI Article Synopsis
- The therapy for childhood acute lymphoblastic leukemia (ALL) has significantly progressed over the last 60 years through 17 treatment protocols developed at St. Jude Children's Research Hospital from 1962 to 2017.
- These protocols focus on creating effective and less toxic treatments, summarizing key elements like objectives, treatment phases, and risk stratification to enhance patient outcomes.
- Advancements in preventive therapy and a risk-based approach have notably increased the cure rates for childhood ALL while minimizing long-term complications, emphasizing the critical need for research in serious diseases like ALL.
Article Abstract
The therapy design of childhood acute lymphoblastic leukemia (ALL) has evolved over the past 60 years. The St. Jude Children's Research Hospital has developed 17 treatment protocols from 1962 to 2017, aiming to have the most effective and least toxic treatment form. This review summarizes each protocol's objectives, inclusion criteria, treatment phases, pharmacological agents, irradiation therapy, response criteria, risk stratification, type of relapse, and overall survival. The enhancement and successful application of preventive therapy for ALL and following a risk-stratified approach have progressively improved the cure rate of childhood ALL, with relatively few adverse sequelae. Moreover, St. Jude's scientific theme serves as a reminder of the principal factor of research directed to a catastrophic disease such as ALL.
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| http://dx.doi.org/10.1186/s43046-022-00126-3 | DOI Listing |
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