AI Article Synopsis
- A 36-year-old woman was diagnosed with relapsing polychondritis after experiencing symptoms like scleritis and saddle nose deformity over a 17-year period.
- Her condition showed only partial improvement despite various treatments, including corticosteroids and immunosuppressants.
- Tocilizumab, a newer medication, was introduced in 2017, leading to significant stabilization of both her systemic and ocular symptoms for the last four years.
Article Abstract
Purpose: To report a challenging case of relapsing polychondritis with bilateral diffuse scleritis, with 17-year follow-up.
Methods: Case report.
Results: A 36-year-old female presented 17 years ago with bilateral diffuse scleritis and peripheral corneal infiltrates. Detailed systemic work-up was negative. Fourteen months later, she developed saddle nose deformity, debilitating myalgias, and severe recurrence of scleritis clinching the diagnosis of relapsing polychondritis. Despite high-dose oral corticosteroids, oral immunosuppressants, and cyclophosphamide infusions and adalimumab infusions, the condition showed waxing and waning over the next decade. In 2017, she was started on Tocilizumab injections after which both the systemic and ocular conditions stabilised and has been remained stable for the past 4 years.
Conclusion: Relapsing polychondritis has a well-known association with scleritis. The ocular disease may precede systemic symptoms in some cases. Newer agent such as tocilizumab appears to be effective in controlling this relentless and recurrent disease.
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| http://dx.doi.org/10.1080/09273948.2022.2058555 | DOI Listing |
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