This is a reflective study aiming to analyze the implementation of Advanced Practice Nursing (APN) and provide perspectives regarding the role of these professionals in the Region of the Americas, particularly in Brazil. Several countries in the world have introduced advanced nursing roles to improve quality of care and reduce health care costs. However, these roles have not been fully implemented in Latin American countries, although some countries have held advanced discussions about it and proposed graduated courses. Brazil fulfills all conditions necessary for the implementation of the education of advanced practice nurses. The investment in advanced practice nurses will result in positive outcomes for the health of the population in a short period of time, with lower costs for governments than other possible actions. It is also a strategic way to address the persistent pressure on health services, whether related to the COVID-19 pandemic or other health needs of the population, and it can be a viable strategy for the provision of care to vulnerable populations and those living in remote areas.
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