A new geranylated xanthone, nigrolineaxanthone AA () together with 18 known compounds (-) were isolated from latex and twig extracts of Planch. ex T. Anderson. Some of the isolated compounds were assessed for their antidiabetic activities and cytotoxicity against three cancer cell lines. Of these, compounds (IC value of 25.8 ± 0.2 µM), (IC value of 124.8 ± 0.7 µM), and (IC value of 44.4 ± 1.1 µM) exhibited the highest -glucosidase inhibitory, -amylase inhibitory, and glycation inhibition activities, respectively. Compound showed glucose consumption and glucose uptake with IC values of 14.2 ± 0.8 µM and 3.1-fold. Compound displayed cytotoxic activity against colon cancer (SW480) with an IC value of 4.3 ± 0.1 µM), while compound showed cytotoxicity against leukemic cancer (K562) with IC value of 4.4 ± 0.3 µM.
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| http://dx.doi.org/10.1080/14786419.2022.2086544 | DOI Listing |
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