AI Article Synopsis
- A case study highlights a patient with microsatellite instability-high (MSI-H) metastatic colorectal cancer who experienced five severe immune-related adverse events (irAEs) during immunotherapy.
- The patient developed conditions such as lymphadenitis, pneumonitis, hypophysitis, thyroiditis, and transverse myelitis after receiving multiple lines of treatment.
- Genomic and cytokine profiling indicated a high tumor mutational burden and notable increases in specific cytokines, suggesting the need for further research on the relationship between MSI-H mCRC and irAEs.
Article Abstract
We report a case of multiple high-grade and rare immune-related adverse events (irAEs) in a patient with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A middle-aged MSI-H mCRC patient with metastases to the lungs and lymph nodes received several lines of chemotherapy and immunotherapy and developed five different high-grade irAEs during immunotherapy, including lymphadenitis, pneumonitis, hypophysitis, thyroiditis and transverse myelitis. Genomic profiling revealed high tumor mutational burden of 43 Muts/Mb. Cytokine profiling showed a threefold increase in MMP-9 shortly prior to the onset of lymphadenitis and a fourfold increase of Ang-1 1 week after the resolution of lymphadenitis. Further studies are warranted to investigate the association of MSI-H mCRC with irAEs and the role of cytokines in predicting irAEs.
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| http://dx.doi.org/10.2217/imt-2021-0298 | DOI Listing |
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