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Serotonergic and cholinergic elements of the hypoxic ventilatory response in developing zebrafish.
J Exp Biol
March 2013
Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5.
The chemosensory roles of gill neuroepithelial cells (NECs) in mediating the hyperventilatory response to hypoxia are not clearly defined in fish. While serotonin (5-HT) is the predominant neurotransmitter in O(2)-sensitive gill NECs, acetylcholine (ACh) plays a more prominent role in O(2) sensing in terrestrial vertebrates. The present study characterized the developmental chronology of potential serotonergic and cholinergic chemosensory pathways of the gill in the model vertebrate, the zebrafish (Danio rerio).
View Article and Find Full Text PDFPharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444.
Eur J Pharmacol
December 2002
Pharmacology and Molecular Biology Research Laboratories, Sankyo Company Limited, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
We examined the pharmacology of (2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride (R-96544), the active form of a novel 5-HT(2A) receptor antagonist, (2R,4R)-4-lauroyloxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride (R-102444). R-96544 produced a concentration-dependent inhibition of platelet aggregation induced by serotonin (5-hydroxytryptamine, 5-HT) alone or in combination with ADP in platelets from humans, monkeys, cats, rabbits, rats and mice. An intravenous administration of R-96544 to rabbits significantly inhibited ex vivo platelet aggregation induced by 5-hydroxytryptamine (5-HT) combined with epinephrine.
View Article and Find Full Text PDFBinding affinity of sarpogrelate to 5-HT(2A) receptor ligand recognition sites in rat renal cortical and mesangial cells in culture.
Gen Pharmacol
July 1999
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
We detected specific binding of 3H-ketanserin (0.6 nM) in rat renal cortical membrane preparations (4.70 +/- 0.
View Article and Find Full Text PDFIs 5-hydroxytryptamine mediating descending inhibition in the neonatal rat spinal cord through different receptor subtypes?
Eur J Pharmacol
December 1993
Department of Physiology, University of Wales, Cardiff, UK.
The long-lasting descending inhibition of lumbar segmental reflexes in the neonatal rat spinal cord has been investigated in vitro by recording from lumbar ventral roots on stimulation of a single lumbar dorsal root. Descending inhibition was elicited by a single stimulus to the latero-ventral thoracic cord. A number of strategies were used to clarify the role of 5-hydroxytryptamine (5-HT) in inhibiting the monosynaptic reflex, the ipsilateral polysynaptic response and the contralateral fast response evoked on the opposite side of the lumbar cord.
View Article and Find Full Text PDFNon-serotonergic 3H-ketanserin binding sites in human platelets: characteristics and interaction with calcium antagonists.
Pharmacol Res
September 1992
Institute of Pharmacological Sciences, University of Milan, Italy.
Here we report the identification of binding sites for 3H-ketanserin in human platelet membranes. At 4 degrees C, 3H-ketanserin binding is saturable (Bmax = 0.58 pmol/mg protein), rapid (equilibrium being attained within 20 min) and reversible.
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