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| http://dx.doi.org/10.3389/fnhum.2022.936090 | DOI Listing |
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Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology.
Alzheimers Res Ther
December 2024
Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
Background: Although separate lines of research indicated a moderating role of sex in both sleep-wake disruption and in the interindividual vulnerability to Alzheimer's disease (AD)-related processes, the quantification of sex differences in the interplay between sleep-wake dysregulation and AD pathology remains critically overlooked. Here, we examined sex-specific associations between circadian rest-activity patterns and AD-related pathophysiological processes across the adult lifespan.
Methods: Ninety-two cognitively unimpaired adults (mean age = 59.
Widening the infantile hypotonia with psychomotor retardation and characteristic Facies-1 Syndrome's clinical and molecular spectrum through NALCN structural analysis.
Front Genet
December 2024
Bioinformatics Unit, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
Introduction: Infantile hypotonia with psychomotor retardation and characteristic facies-1 (IHPRF1, MIM#615419) is a rare, birth onset, autosomal recessive disorder caused by homozygous or compound heterozygous truncating variants in gene (MIM#611549) resulting in a loss-of-function effect.
Methods: We enrolled a new IHPRF1 patients' cohort in the framework of an international multicentric collaboration study. Using specialized pathogenicity predictors and structural analyses, we assessed the mechanistic consequences of the deleterious variants retrieved on NALCN structure and function.
DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa.
Front Immunol
December 2024
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, but considering the key role played by the biological clock in the control of immune/inflammatory processes the derangement of circadian and ultradian pathways could be hypothesized.
Methods: We analyzed genome-wide DNA methylation patterns in peripheral blood from 24 HS cases and 24 controls using the Infinium HumanMethylation450 BeadChip array (Illumina), followed by bioinformatics and statistical analyses.
Baboons, bacteria, and biological clocks address an age-old question.
Elife
December 2024
Department of Anthropology and Archaeology, University of Calgary, Calgary, Canada.
Studying the fecal microbiota of wild baboons helps provide new insight into the factors that influence biological aging.
View Article and Find Full Text PDFSlow stroking evokes a more pleasant sensation but similar autonomic nervous system response than rhythmic touching.
Biol Psychol
November 2024
Institute of Psychology, Károli Gáspár University of the Reformed Church in Hungary, Budapest, Hungary; Ádám György Psychophysiology Research Group, Budapest, Hungary.
Stimulation of C-tactile afferents with gentle slow stroking of the hairy skin, also called affective touch, evokes a pleasant sensation. We intended to describe psychological and tonic physiological changes evoked by slow stroking, as well as associations between pleasantness of skin sensation and physiological changes and trait-like self-reported characteristics (i.e.
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