AI Article Synopsis
- The study aimed to assess how metformin affects kidney and heart function, as well as inflammation in patients with diabetic nephropathy.
- A total of 88 patients were divided into two groups: one received metformin while the other received liraglutide, allowing for comparisons in various health metrics.
- Results showed that metformin significantly improved kidney and heart function, reduced inflammatory markers, and was more effective than liraglutide for these patients.
Article Abstract
Objective: To investigate the effect of metformin on renal function, cardiac function, and inflammatory response in diabetic nephropathy and its protective mechanism.
Methods: A total of 88 patients with diabetic nephropathy who were admitted to our hospital from April 2019 to October 2020 were recruited and grouped according to different treatment methods, namely, the experimental group ( = 44) and the control group ( = 44). The patients in the experimental group were treated with metformin, and the patients in the control group were treated with liraglutide injection (nonmetformin). Left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and inflammatory response (hs-CRP, TNF-, IL-6) were compared.
Results: Compared with corresponding values before treatment, BUN, Scr, hs-CRP, TNF-, IL-6, LVEDD, and LVESD were decreased after treatment, whereas LVEF was increased (all < 0.05), with significant change in the experimental group (all < 0.001).
Conclusion: Metformin can effectively improve the level of renal function and cardiac function in patients with diabetic nephropathy and help patients control and reduce the body's inflammatory response, and its therapeutic efficacy is superior to that of liraglutide injection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187446 | PMC |
| http://dx.doi.org/10.1155/2022/8326767 | DOI Listing |
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Article Synopsis
- The study investigated the role of inflammation-related biomarkers (SII, SIRI, NLR, PLR) in predicting mid-term mortality and restenosis in patients with peripheral artery disease (PAD).
- During an average follow-up of about 21 months, researchers found that higher levels of these biomarkers correlated with increased mortality rates, particularly highlighting NLR as a significant independent risk factor.
- However, no significant links were established between these biomarkers and the occurrence of restenosis in the study participants.
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