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Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease.
Histochem Cell Biol
December 2024
Institute of Pathology, Klinikum Bayreuth, 95445, Bayreuth, Germany.
A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies.
View Article and Find Full Text PDFEvaluation of enterochromaffin-like cell hyperplasia can help categorize patients with Helicobacter-negative atrophic gastritis.
Am J Clin Pathol
December 2024
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, US.
Objectives: Atrophic gastritis (AG) is characterized by atrophy of gastric glands-in particular, oxyntic glands-in the setting of chronic inflammation; it is often autoimmune. The diagnosis is confirmed by immunohistochemistry (IHC) for gastrin (to confirm biopsy site), and pathologists often use IHC for neuroendocrine markers to evaluate for enterochromaffin-like cell hyperplasia (ECL-H). The utility of neuroendocrine staining is unclear, and we undertook this study to determine whether ECL pattern provided any additional information in cases of Helicobacter-negative AG.
View Article and Find Full Text PDFObjective: Detailed study of the morphological characteristics of autoimmune gastritis (AIG), assessment of the possibilities and prospects for morphological diagnosis of this disease.
Material And Methods: The study included 63 patients with AIG and 25 patients with chronic atrophic gastritis, who were examined in the clinics of Sechenov University from 2021 to 2023.
Results: During the study, it was found that in biopsies of the antrum of the stomach in 90.
BAFF Blockade Attenuates B Cell MALT Formation in Conditional Nlrc5-Deficient Mice With Helicobacter felis Infection.
Eur J Immunol
December 2024
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Helicobacter infection is a key cause of gastric B cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell-activating factor (BAFF), a major driver of B cell proliferation and many B cell disorders, in this malignancy using a model in which conditional knockout mice for NOD-like receptor family CARD domain-containing 5 (Nlrc5) are infected with Helicobacter felis. Gastric BAFF production was significantly increased in H.
View Article and Find Full Text PDFIL-17A in gastric carcinogenesis: good or bad?
Front Immunol
December 2024
Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China.
Cytokines, which are important to the tumor microenvironment (TME), play critical roles in tumor development, metastasis, and immune responses. Interleukin-17(IL-17) has emerged as a key biomarker in many malignancies; however, its precise involvement in gastric cancer is less fully understood. Elevated levels of IL-17 have been observed in stomach diseases such as infection and autoimmune gastritis, indicating that a sustained Th17 response may precede the development of gastric cancer.
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