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Infective Endocarditis by Biofilm-Producing Methicillin-Resistant -Pathogenesis, Diagnosis, and Management.
Antibiotics (Basel)
November 2024
Division of Pulmonary and Critical Care, Unity Point Health at St. Luke's Regional Medical Center, 2720 Stone Park Blvd, Sioux City, IA 51104, USA.
Infective endocarditis (IE) is a life-threatening condition with increasing global incidence, primarily caused by , especially methicillin-resistant strains (MRSA). Biofilm formation by is a critical factor in pathogenesis, contributing to antimicrobial resistance and complicating the treatment of infections involving prosthetic valves and cardiovascular devices. Biofilms provide a protective matrix for MRSA, shielding it from antibiotics and host immune defenses, leading to persistent infections and increased complications, particularly in cases involving prosthetic materials.
View Article and Find Full Text PDFEvolution of community-associated MRSA: a 20-year genomic and epidemiological study in Region Örebro County, Sweden.
Front Microbiol
December 2024
Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Background: Methicillin-resistant (MRSA) has been an issue in healthcare since the 1960s. It was initially found only in healthcare facilities, but in the late 1990s it began to be seen with no healthcare connexion. The mechanisms of intercontinental and national spread are not fully understood, as sometimes novel outbreaks occur without any identifiable source or connexion to locally dominant clonal clusters.
View Article and Find Full Text PDFEvaluating bias in electronic health record data: using agent-based models to examine whether geographic disparities in community-acquired Methicillin-resistant Staphylococcus aureus are due to differential healthcare-seeking behaviors.
Am J Epidemiol
January 2025
Center for Animal Disease Modeling and Surveillance, Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Electronic health records (EHR) are increasingly used in public health research. However, biases may exist when using EHR due to whether someone is captured in the data. Assessing the impact of bias in generating disparities identified with EHR data is difficult because information about healthcare-seeking behaviors is not included in the record.
View Article and Find Full Text PDFDynamically Assembling Magnetic Nanochains as New Generation of Swarm-Type Magneto-Mechanical Nanorobots Affecting Biofilm Integrity.
Adv Healthc Mater
January 2025
Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UPS), 205 Route de Narbonne, Toulouse, 31400, France.
Article Synopsis
- Bacterial resistance is increasing, necessitating innovative strategies for effective antibiotic treatment.
- Ultra-short propelling magnetic nanochains, designed to mimic natural bacterial movement, enhance the efficacy of antibiotics against biofilm-forming Staphylococcus epidermidis by converting resistant bacteria into sensitive ones.
- These nanochains, activated by a low-intensity rotating magnetic field, operate by mechanically disrupting bacterial structures and working synergistically with antibiotics to completely eliminate biofilms.
Clonal shift and impact of azithromycin use on antimicrobial resistance of Staphylococcus aureus isolated from bloodstream infection during the COVID-19 pandemic.
Sci Rep
January 2025
Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21951-902, Brazil.
Staphylococcus aureus is a relevant pathogen in bloodstream infections (BSI), and the emergency of the COVID-19 pandemic increased its antimicrobial resistance. S. aureus isolates from BSI (September/2019 - March/2021) were analyzed phenotypically and molecularly, in addition to the clinical features of the patients.
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