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"Someday, I'll be an ancestor:" Understanding indigenous intergenerational connectedness through qualitative research to inform measure development.
Am J Community Psychol
March 2025
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Intergenerational connectedness broadly encompasses relations among humans, lands, and all living and spiritual beings, and functions as an important part of Indigenous well-being. Many public health campaigns and interventions aim to promote connectedness to support holistic wellness and reduce health inequities. Currently, however, there are no measurement tools to assess intergenerational connectedness to support culturally grounded research and program evaluation.
View Article and Find Full Text PDFDevelopment of a Calreticulin-targeting Glycan Ligand Based on a Hybrid Binding Concept.
Glycobiology
March 2025
Department of Science and Technology, Seikei University, Tokyo 180-8633, Japan.
Calreticulin (CRT), a chaperone that possesses both lectin and chaperone domains, is localized in the endoplasmic reticulum (ER). CRT has diverse functions and localizations; thus, CRT is a multifunctional protein. Particularly in the ER, CRT mainly aids in the proper folding of nascent glycoproteins as lectin chaperones.
View Article and Find Full Text PDFThe Psychobiological Toll of Chronic Conflict: Posttraumatic Stress Symptoms, Emotion Dysregulation, and Physiology in a Conflict-Exposed Community in South Sudan.
Chronic Stress (Thousand Oaks)
March 2025
Department of Psychology, The New School for Social Research, New York, USA.
Background: Mass conflict and related displacement in South Sudan has created a significant mental health need, however extant research on the impact of conflict is limited among South Sudanese people and has predominantly relied on Western-developed self report measures.
Method: A total of 195 South Sudanese adults who work in both civil society and government leadership positions participated in a psychophysiological assessment of heart rate variability (HRV) and self-reported PTSD and emotion dysregulation symptoms to participation in the Trauma-Informed Community Empowerment (TICE) Framework, developed and implemented by the Global Trauma Project (GTP). We utilized measures of heart rate variability to determine parasympathetic activity, which may be associated with difficulties responding to stressors as well as long-term physical health morbidity and mortality.
Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies.
Front Immunol
March 2025
Department of Public Laboratory, The Third People's Hospital of Kunming City/Infectious Disease Clinical Medical Center of Yunnan Province, Kunming, Yunnan, China.
Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite the limited number of studies on post-COVID conditions, particularly those extending beyond three months, these studies provide valuable insights.
View Article and Find Full Text PDFVericiguat in patients with heart failure and implantable cardioverter-defibrillator.
Drugs Context
March 2025
Cardiology Department, Arrhythmia Unit, University Hospital La Paz, Madrid, Spain.
Background: This analysis assesses the effectiveness and tolerability profile of vericiguat in patients with heart failure with reduced ejection fraction (HFrEF) and implantable cardioverter-defibrillator, with an emphasis on the emergence of ventricular arrhythmias.
Methods: Retrospective analysis of patients with HFrEF and implantable cardioverter-defibrillator who started treatment with vericiguat in daily clinical practice in a tertiary university hospital in Spain.
Results: The study population comprised 14 patients treated since January 2023.
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