AI Article Synopsis
- - The Rosaceae family includes various fruits like peach, apple, and strawberry, with specific allergens such as Bet v 1, profilin, and lipid transfer proteins (LTP) causing oral and generalized allergic reactions.
- - A case study of a 15-year-old boy revealed he had generalized allergic symptoms triggered by strawberry when coupled with exercise, confirmed through an oral food challenge test.
- - The study highlights strawberry GRP as a potential allergenic component responsible for exercise-induced symptoms in this case, marking the first investigation into this relationship and indicating a need for further research on strawberry allergies.
Article Abstract
Background: The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have been reported to include Bet v 1 and profilin, which mainly cause oral symptoms, and lipid transfer protein (LTP). Recently, gibberellin-regulated protein (GRP) has been identified as an allergen that induces generalized symptoms in peach-, orange-, and plum-related allergies. Most patients with food allergies induced by GRP show allergic symptoms accompanied by cofactors, such as exercise or drugs. To date, there are very few reports of generalized symptoms induced by strawberry.
Case Presentation: We evaluated the reactivity of strawberry GRP in a 15-year-old boy who was confirmed to have generalized symptoms induced by strawberry with exercise using an oral food challenge test (OFCT). The patient's serum exhibited a strong positive reaction to strawberry GRP but not to peach GRP or peach LTP. The patient's basophils reacted to strawberry and peach GRP but not to peach LTP.
Conclusions: Strawberry GRP may be a causative component for strawberry with exercise-induced generalized symptoms in this patient. This is the first study to investigate the role of GRP in strawberry with cofactor-induced allergic symptoms. Further epidemiological and clinical researches are necessary to improve diagnostic and therapeutic approaches for patients with strawberry allergy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188171 | PMC |
| http://dx.doi.org/10.1186/s13223-022-00692-0 | DOI Listing |
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