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| http://dx.doi.org/10.1016/j.ijsu.2022.106698 | DOI Listing |
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Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia.
J Transl Med
August 2024
Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Negrar, Italy.
Article Synopsis
- A study conducted on aged patients with COVID-19 pneumonia at a hospital in Italy aimed to define the immune responses related to the infection, particularly focusing on the effects of vaccination.
- The study analyzed humoral responses (like antibody production) and cellular responses (like T-cell counts), comparing vaccinated and unvaccinated patients to understand their immunity levels and disease severity.
- Results showed unvaccinated patients had worse outcomes and lower immune responses, with vaccinated individuals exhibiting higher antibody levels and T-cell counts, especially against the Delta variant.
Characterization of BA-4 and its biocontrol potential against -related apple replant disease.
Front Plant Sci
April 2024
College of Plant Protection, State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Apple replant disease (ARD), caused by pathogens, is a formidable threat to the renewal of apple varieties in China, necessitating the development of effective and sustainable control strategies. In this study, the bacterial strain BA-4 was isolated from the rhizosphere soil of healthy apple trees in a replanted orchard, demonstrating a broad-spectrum antifungal activity against five crucial apple fungal pathogens. Based on its morphology, physiological and biochemical traits, utilization of carbon sources, and Gram stain, strain BA-4 was tentatively identified as .
View Article and Find Full Text PDFSARS-CoV-2 Omicron Subvariants Do Not Differ Much in Binding Affinity to Human ACE2: A Molecular Dynamics Study.
J Phys Chem B
April 2024
Institute of Physics, Polish Academy of Sciences, al. Lotnikow 32/46, Warsaw 02-668, Poland.
The emergence of the variant of concern Omicron (B.1.1.
View Article and Find Full Text PDFS-Gene Target Failure as an Effective Tool for Tracking the Emergence of Dominant SARS-CoV-2 Variants in Switzerland and Liechtenstein, Including Alpha, Delta, and Omicron BA.1, BA.2, and BA.4/BA.5.
Microorganisms
February 2024
Laboratory Dr. Risch, 9470 Buchs, Switzerland.
Article Synopsis
- During the COVID-19 pandemic, the Dr. Risch medical group utilized a specific RT-PCR testing kit for diagnosing infections in Switzerland and Liechtenstein, which targeted three genes essential for identifying the virus.
- The emergence of the Alpha variant (B.1.1.7) led to a notable diagnostic issue, where the S-gene target was absent due to genetic deletions, marking it as an early indicator of new variants; this phenomenon was also seen in Omicron but not with the Delta variant.
- Over two years, the group studied the significance of S-gene target failure (SGTF) as a signal for identifying variants, confirming that differences in cycle threshold values could help distinguish true SGTF cases from discrepancies
Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa.
S Afr J Infect Dis
December 2023
Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Background: The emergence of genetic variants of SARS-CoV-2 was associated with changing epidemiological characteristics throughout coronavirus disease 2019 (COVID-19) pandemic in population-based studies. Individual-level data on the clinical characteristics of infection with different SARS-CoV-2 variants in African countries is less well documented.
Objectives: To describe the evolving clinical differences observed with the various SARS-CoV-2 variants of concern and compare the Omicron-driven wave in infections to the previous Delta-driven wave.
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