We characterize absorption-time distributions for birth-death Markov chains with an absorbing boundary. For "extinction-prone" chains (which drift on average toward the absorbing state) the asymptotic distribution is Gaussian, Gumbel, or belongs to a family of skewed distributions. The latter two cases arise when the dynamics slow down dramatically near the boundary. Several models of evolution, epidemics, and chemical reactions fall into these classes; in each case we establish new results for the absorption-time distribution. Applications to African sleeping sickness are discussed.
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http://dx.doi.org/10.1103/PhysRevLett.128.218301 | DOI Listing |
Animals (Basel)
August 2024
Pharmacology, Department of Biomedical Sciences, Veterinary Faculty, Institute of Biomedicine (IBIOMED), University of Leon, 24071 Leon, Spain.
Menbutone is a choleretic agent currently used in Europe to treat digestive disorders in livestock and dogs. Pharmacokinetic parameters were established in 4-month Holstein calves after intravenous (IV) and intramuscular (IM) administration. The drug was administered to 12 animals (10 mg/kg) for both IV and IM routes following a crossover design.
View Article and Find Full Text PDFJ Vet Pharmacol Ther
August 2024
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
The objective of this study was to determine the pharmacokinetics of enrofloxacin and its metabolite, ciprofloxacin, in Nanyang cattle after a single intravenous (IV), and intramuscular (IM) administration of enrofloxacin at 2.5 mg/kg body weight (BW). Blood samples were collected at predetermined time points.
View Article and Find Full Text PDFJ R Soc Interface
June 2024
School of Sciences, Beijing University of Posts and Telecommunications, Beijing, People's Republic of China.
The speed of evolution on structured populations is crucial for biological and social systems. The likelihood of invasion is key for evolutionary stability. But it makes little sense if it takes long.
View Article and Find Full Text PDFJ Clin Psychopharmacol
December 2023
From the University Center of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
J Occup Environ Hyg
January 2024
Otto H. York Department and Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, New Jersey.
A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for bromochloromethane. These concentrations were reconstructed based on chemical blood levels measured in 4 hr, with errors varying from 0.
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