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The comparative effectiveness of medicinal cannabis for chronic pain versus prescription medication treatment.
Pain
January 2025
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Reviews of the effectiveness of medicinal cannabis for chronic pain vary in their conclusions. IASP has identified that a key missing evidence in this debate is data from observational cohort studies, analyzed with comparative effectiveness methods. In a medically supervised context to the use of marijuana for chronic pain, we identified 440 patients certified for medical marijuana by pain specialists in a single healthcare system.
View Article and Find Full Text PDFDexmedetomidine for analgesia and sedation for procedural pain or discomfort in newborn infants.
Cochrane Database Syst Rev
January 2025
Department of Clinical Sciences Lund, Paediatrics, Lund University, Skåne University Hospital, Lund, Sweden.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of dexmedetomidine compared with opioids, non-opioids and placebo in providing sedation and analgesia for procedural pain in newborn infants.
View Article and Find Full Text PDFReal-world clinical and economic impacts of delayed rotator cuff repair surgery in Japan: analysis of a large claims database.
JSES Rev Rep Tech
February 2025
Smith & Nephew, Asia Pacific, Singapore, Singapore.
Background: In patients with rotator cuff tears (RCTs), there is a lack of evidence regarding the impact of the timeliness of rotator cuff repair (RCR) surgery on treatment outcomes and overall healthcare burden. This study aimed to understand the impact of early vs. delayed RCR on real-world healthcare costs and resource use (HCRU) in Japan.
View Article and Find Full Text PDFPractice Advisory for Postoperative Pain Management of Thoracic Surgical Patients: Executive Summary: A Report by Society of Cardiovascular Anesthesiologists.
J Cardiothorac Vasc Anesth
December 2024
Department of Anesthesiology, Missoula Anesthesiology and The International Heart Institute of Montana, Missoula, MT.
Patients after thoracic surgery experience significant pain that can disrupt normal respiratory mechanics, increase the risk of respiratory complications, and impair recovery. Poorly controlled postoperative pain can develop into persistent postoperative pain. In addition, using opioids for pain control in the thoracic surgical population makes them more susceptible to opioid-related side effects due to their pre-existing comorbidities.
View Article and Find Full Text PDFUnveiling the Dichotomic Nature of VEGFA in neuropathic pain: A path to targeted therapeutics.
Neurotherapeutics
January 2025
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA; Pain Research and Integrated Neuroscience Center (PRINC), College of Medicine, University of Florida, Gainesville, FL, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:
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