AI Article Synopsis
- A study focused on the prevalence of genetic rearrangements associated with a good prognosis in children with acute lymphoblastic leukemia (ALL) in Mexico found lower rates compared to Caucasian populations.
- Researchers developed a new TaqMan RT-qPCR method to assess four specific genetic rearrangements in Hispanic children with ALL from Mexico City.
- The findings revealed a low prevalence of these rearrangements (7.7%, 3.3%, and 2.8%), aligning with previous studies on Mexican and Hispanic children, highlighting the need to further understand genetic factors in ALL among diverse populations.
Article Abstract
is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City. The prevalence of common fusion gene transcripts was as follows: 7.7%; 3.3%; and 2.8%, and was observed with low prevalence (10.5%) in comparison to that reported for developed countries. This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations. The confirmation of a low prevalence of in children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171364 | PMC |
| http://dx.doi.org/10.3389/fped.2022.837656 | DOI Listing |
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