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Aim: To evaluate if VSL#3 [a high-concentration multi-strain probiotic mix containing one strain of BT01, three strains of ( BB02; subspecies [subsp.] BL03, previously identified as BL03; and subsp. BI04, previously identified as BI04), and four strains of ( BA05, BP06, BP07, and BD08, previously identified as subsp. BD08)] therapy could improve hepatic parameters.
Methods: We enrolled 60 Caucasian patients aged ≥ 18 years of either sex with the diagnosis of non-alcoholic fatty liver disease (NAFLD), according to practice guidance, in a double-blind, placebo-controlled study. Patients were randomized to take placebo or VSL#3, 2 sachets/day in the morning for 3 months. VSL#3 and placebo were self-administered.
Results: We did not observe any change in body mass index (BMI), circumferences, fasting plasma glucose (FPG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and adiponectin (ADN) with neither treatment. A statistically significant triglycerides (Tg) decrease ( < 0.05 vs. baseline, and < 0.05 vs. placebo, respectively) and high-sensitivity C-reactive protein (Hs-CRP) decrease ( < 0.05 vs. baseline) was observed in the group of patients being treated with VSL#3 compared with placebo. Transaminases and gamma-glutamyltransferase (γ-GT) were significantly reduced in VSL#3 group ( < 0.05 vs. baseline and placebo, respectively) compared with the placebo group. Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and hepatic steatosis index (HSI) were significantly lower than the VSL#3 group ( < 0.05 vs. baseline and placebo, respectively) compared with the placebo group. All patients reported an improvement or the disappearance of hepatic steatosis.
Conclusion: Probiotic therapy with VSL#3 ameliorates hepatic parameters and echography grading, while reducing Tg and the inflammatory status, without any difference between men and women.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172906 | PMC |
| http://dx.doi.org/10.3389/fnut.2022.846873 | DOI Listing |
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