2529-993X4062022Jun-JulEnferm Infecc Microbiol Clin (Engl Ed)Cerebrospinal fluid drainage-related ventriculitis due to multidrug-resistant microorganisms.322325322-32510.1016/j.eimce.2020.12.005S2529-993X(22)00115-0The aim of the study was to analyze the clinical and microbiological characteristics of adult patients with cerebrospinal fluid (CSF) drainage-related ventriculitis.Retrospective study from January 2010 to June 2019 performed in the Complexo Hospitalario Universitario de Vigo (Spain). Cases of CSF drainage-related ventriculitis in patients ≥18-year-old were gathered. Clinical characteristics of patients, type of drainage devices, management and microbiological isolates were analyzed.Ninety-one episodes of CSF drainage-related ventriculitis were identified. The most frequent organisms isolated were Gram-positive cocci (65%), mainly Staphylococcus epidermidis (48%). Multidrug-resistant microorganisms were detected in 21 episodes (23%). In multivariate analysis, the independent factors related with multidrug-resistant ventriculitis were the length of hospital stay >14 days (HR 6.7; 95%CI 1.75-25.86, p=0.006) and previous antimicrobial therapy (HR 5.58; 95%CI 1.44-21.65, p=0.013).Our study shows a large number of drainage-related ventriculitis episodes caused by multidrug-resistant organisms and reinforce the importance of a judicious use of antibiotics.Copyright © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.Solo-PeleteiroAdrianaAInfectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain.DiéguezPatriciaPInfectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain.Pérez-RodríguezMaría TeresaMTInfectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain; Instituto de Investigación Biomédica Galicia Sur, Spain. Electronic address: perezrodriguezmt@gmail.com.GalárragaRaul ARADepartment of Neurosurgery, Complexo Hospitalario Universitario de Vigo, Spain.Pérez-LandeiroAntonioADepartment of Pharmacy, Complexo Hospitalario Universitario de Vigo, Spain.Álvarez-FernándezMaximilianoMInstituto de Investigación Biomédica Galicia Sur, Spain; Department of Microbiology, Complexo Hospitalario Universitario de Vigo, Spain.engJournal Article