New disease challenges, societal demands and better or novel types of data, drive innovations in the structure, formulation and analysis of epidemic models. Innovations in modelling can lead to new insights into epidemic processes and better use of available data, yielding improved disease control and stimulating collection of better data and new data types. Here we identify key challenges for the structure, formulation, analysis and use of mathematical models of pathogen transmission relevant to current and future pandemics.
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| http://dx.doi.org/10.1016/j.epidem.2022.100588 | DOI Listing |
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Mid-infrared spectra of dried and roasted cocoa ( L.): A dataset for machine learning-based classification of cocoa varieties and prediction of theobromine and caffeine content.
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Centro Surcolombiano de Investigación en Café (CESURCAFÉ), Departamento de Ingeniería Agrícola, Universidad Surcolombiana, Neiva-Huila 410001, Colombia.
This paper presents a comprehensive dataset of mid-infrared spectra for dried and roasted cocoa beans ( L.), along with their corresponding theobromine and caffeine content. Infrared data were acquired using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, while High-Performance Liquid Chromatography (HPLC) was employed to accurately quantify theobromine and caffeine in the dried cocoa beans.
View Article and Find Full Text PDFCharacterization of Amorphous Ibrutinib Thermal Stability.
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January 2025
Department of Chemical Engineering, University of Chemistry and Technology, Technická 3, Prague 6, Dejvice 166 28, Czech Republic.
The choice of method for drug amorphization depends on various factors, including the physicochemical properties of the active pharmaceutical ingredients, the desired formulation, and scalability requirements. It is often important to consider a combination of methods or the use of excipients to further enhance the stability and performance of the amorphous drug. This study presents a comparison of techniques including melt quench, hot melt extrusion, solvent evaporation, ball milling, and lyophilization used for the preparation of amorphous ibrutinib.
View Article and Find Full Text PDFNutritional Evaluation and Free Radical Scavenging Activity of Nano-formulated Selenium-Moringa Peregrine Seed Extract as a Promising Suppressor of TGF-β1/P38/NF-kβ Signaling Pathway in HgCl2 Intoxicated-Mice.
Curr Pharm Biotechnol
January 2025
Department of Nutrition, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Background: Moringa peregrina, renowned for its extensive health benefits, continues to reveal its therapeutic potential through ongoing research. The synthesis of Moringa peregrina extract-selenium nanoparticles (MPE-SeNPs) has emerged as a promising approach in developing versatile therapeutic agents.
Objective: To evaluate the protective effects of MPE-SeNPs against oxidative damage and inflammation caused by HgCl2 exposure in mice.
Impact of soy/pea protein isolate-oil interactions on the physicochemical and structural properties of high-moisture texturized proteins under different oil concentrations.
Int J Biol Macromol
January 2025
Department of Agricultural Biotechnology, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 08826, Republic of Korea; Research Institute for Agriculture and Life Sciences, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 08826, Republic of Korea; Center for Food and Bioconvergence, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 08826, Republic of Korea. Electronic address:
This study investigated the effects of oil addition on the physical and chemical properties of high-moisture texturized proteins (HMTPs), focusing on soy protein isolate (SPI) and pea protein isolate (PPI). Rheological analysis revealed contrasting behaviors: SPI exhibited decreased rheological parameters at low oil concentrations (1, 3 %), followed by a significant increase at higher concentrations (5, 10 %), whereas PPI showed a consistent decline across all oil concentrations. The superior emulsifying and gelling abilities of SPI resulted in stronger protein-protein interactions and greater hardness at higher oil concentrations.
View Article and Find Full Text PDFEffects of linkers on the development of liposomal docetaxel-glutathione prepared by active click loading.
Int J Pharm
January 2025
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016 China. Electronic address:
Loading drug-maleimide (MAL) conjugates into liposomes preloaded with glutathione (GSH) can prepare the liposome encapsulating GSH-conjugated prodrugs, which serve as a feasible way to construct liposomal formulation. However, the effects ofthelinker on the development of this liposomal system remained unclear. Herein, docetaxel (DTX)-MAL conjugates linked by various linkers were used for such studies.
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