Background: Human papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed.
Methods: We assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV.
Results: Detection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence.
Conclusions: Detection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.
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| http://dx.doi.org/10.1093/infdis/jiac223 | DOI Listing |
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